ReviewNutrients2021
Has Menstruation Disappeared? Functional Hypothalamic Amenorrhea-What Is This Story about?
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Effect of the Menstrual Cycle on Energy Intake: A Systematic Review and Meta-analysis.Nutrition reviews · 2025Pooled it
- Impact of Physical Activity and Sedentary Behavior on Spontaneous Female and Male Fertility: A Systematic Review.Journal of physical activity & health · 2023Pooled it
- Psychological factors in functional hypothalamic amenorrhea: A systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Metabolic and Endocrine Alterations in Underweight and Normal-Weight Women with Functional Hypothalamic Amenorrhea.Journal of clinical medicine · 2025Article
- Alterations in menstrual characteristics and associated factors in Chinese women post SARS-CoV-2 infection: a cross-sectional study.BMC women's health · 2025Article
- Functional hypothalamic amenorrhea in adolescent athletes impairs bone accrual and increases fracture risk.Frontiers in endocrinology · 2025Review
- Developing an educational resource for people experiencing eating disorders during the menopause transition: A qualitative co-design study.Journal of eating disorders · 2024Article
- Dietary and Lifestyle Management of Functional Hypothalamic Amenorrhea: A Comprehensive Review.Nutrients · 2024Review
- Retrospective Analysis of Effective Management Strategies for Primary Amenorrhea of Reproductive Age in Saudi Arabia.Life (Basel, Switzerland) · 2024Article
- Effects of physical activity on infertility in reproductive females.Reproductive biology and endocrinology : RB&E · 2024Article
- The risk of low energy availability among athlete females in Saudi Arabia: a cross-sectional study.Frontiers in public health · 2024Article
- Functional hypogonadism in adolescence: an overlooked cause of secondary hypogonadism.Endocrine connections · 2023Review
- Menstrual Cycle Irregularity in Adolescence Is Associated With Cardiometabolic Health in Early Adulthood.Journal of the American Heart Association · 2023Article
- Review
- Low-Dose Estrogens as Neuroendocrine Modulators in Functional Hypothalamic Amenorrhea (FHA): The Putative Triggering of the Positive Feedback Mechanism(s).Biomedicines · 2023Review
- Cognition, Behavior, Sexuality, and Autonomic Responses of Women with Hypothalamic Amenorrhea.Brain sciences · 2022Article
- Nutrition in Gynecologic Disease.Nutrients · 2022Article
- Emotional and autonomic response to visual erotic stimulation in patients with functional hypothalamic amenorrhea.Frontiers in endocrinology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional hypothalamic amenorrhea (FHA) is a very common condition affecting women of procreative age. There are many reasons for this disorder, including a low availability of energy in the diet, low micro- and macronutrient intake, overly intensive physical activity, disturbed regeneration processes, sleep disorders, stress, and psychological disorders. The main determinant is long-term stress and an inability to handle the effects of that stress. FHA is a very complex disorder and often goes undiagnosed. Moreover, therapeutic interventions do not address all the causes of the disorder, which could have implications for women's health. As shown by scientific reports, this condition can be reversed by modifying its causes. This review of the literature aims to update the current knowledge of functional hypothalamic amenorrhea and underscores the complexity of the disorder, with particular emphasis on the nutritional aspects and potential interventions for restoring balance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.