Evidence map›Paper›PMID 34444974›Full record

Trial reportNutrients2021

Daniel Merenstein, Claire M Fraser, Robert F Roberts, Tian Liu, Silvia Grant-Beurmann, Tina P Tan, Keisha Herbin Smith, Tom Cronin, Olivia A Martin, Mary Ellen Sanders and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03755765 (Exploratory Pilot Studies to Demonstrate Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03755765 early_phase1completednot on this map

Exploratory Pilot Studies to Demonstrate Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics

TypeinterventionalSponsorGeorgetown UniversityRan2019 to 2020Enrolled66ConditionsAntibiotic-associated DiarrheaArmsAmoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, BB-12, Control
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Trial
  4. Trial
  5. Metabolic signature ofEuropean journal of nutrition · 2023
    Trial
  6. Trial
  7. Prebiotic Treatment in People With Schizophrenia.Journal of clinical psychopharmacology
    Trial
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Microorganisms · 2026
    Article
  14. Review
  15. Review
  16. Health benefits ofFrontiers in microbiology · 2026
    Review
  17. Article
  18. Article
  19. A Synbiotic ofNutrients · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Daniel MerensteinDepartment of Family Medicine, Georgetown University Medical Center, Washington, DC 20057, USA.
Claire M FraserInstitute for Genomic Sciences, Departments of Medicine and Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Robert F RobertsDepartment of Food Science, The Pennsylvania State University, University Park, PA 16802, USA.
Tian LiuDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
Silvia Grant-BeurmannInstitute for Genomic Sciences, Departments of Medicine and Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Tina P TanDepartment of Family Medicine, Georgetown University Medical Center, Washington, DC 20057, USA.
Keisha Herbin SmithDepartment of Family Medicine, Georgetown University Medical Center, Washington, DC 20057, USA.
Tom CroninDepartment of Family Medicine, Georgetown University Medical Center, Washington, DC 20057, USA.
Olivia A MartinInstitute for Genomic Sciences, Departments of Medicine and Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Mary Ellen SandersDairy & Food Culture Technologies, Centennial, CO 80122, USA.ORCID 0000-0001-6321-3423
Sean C LucanDepartment of Family and Social Medicine, Albert Einstein College of Medicine, Montefiore Health System, Bronx, NY 10461, USA.ORCID 0000-0002-4447-9709
Maureen A KaneDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USGeorgetown University · USAlbert Einstein College of Medicine · USPennsylvania State University · US

Funding

Exploratory Pilot Studies to Demonstrate Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for ProbioticsR33AT009622 · NCCIH · GEORGETOWN UNIVERSITY · PI MERENSTEIN, DANIEL J · 2020 to 2022
$1.2M
Exploratory Pilot Studies to Demonstrate Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for ProbioticsR61AT009622 · NCCIH · GEORGETOWN UNIVERSITY · PI FRASER, CLAIRE M., MERENSTEIN, DANIEL J · 2018 to 2019
$649k
NCCIH NIH HHS R33 AT009622NCCIH NIH HHS R61 AT009622NCCIH NIH HHS R61AT009622University of Maryland School of Pharmacy Mass Spectrometry Center SOP1841-IQB2014
6 · The paper itself

Abstract

The administration of broad-spectrum antibiotics is often associated with antibiotic-associated diarrhea (AAD), and impacts gastrointestinal tract homeostasis, as evidenced by the following: (a) an overall reduction in both the numbers and diversity of the gut microbiota, and (b) decreased short-chain fatty acid (SCFA) production. Evidence in humans that probiotics may enhance the recovery of microbiota populations after antibiotic treatment is equivocal, and few studies have addressed if probiotics improve the recovery of microbial metabolic function. Our aim was to determine if

Indexed as

FecesGastrointestinal MicrobiomeAdolescentAdultAgedAnti-Bacterial AgentsBifidobacterium animalisColonDiarrheaFatty Acids, VolatileGastrointestinal TractHumansMiddle AgedProbioticsYogurtYoung AdultAnti-Bacterial AgentsFatty Acids, Volatileabundanceantibiotic-induced perturbationBifidobacteriumdiversitygut microbiotaprobioticshort-chain fatty acid

Identifiers

PMID34444974
PMCPMC8398419
OpenAlexW3195289809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.