Evidence map›Paper›PMID 34444972›Full record

ArticleNutrients2021

Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota.

Ryuta Ejima, Masahiro Akiyama, Hiroki Sato, Sawako Tomioka, Kyosuke Yakabe, Tatsuki Kimizuka, Natsumi Seki, Yumiko Fujimura, Akiyoshi Hirayama, Shinji Fukuda and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. DietaryAnimals : an open access journal from MDPI · 2026
    Article
  2. Article
  3. Article
  4. International journal of molecular sciences · 2023
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ryuta EjimaResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Masahiro AkiyamaResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Hiroki SatoResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Sawako TomiokaResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Kyosuke YakabeResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Tatsuki KimizukaResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Natsumi SekiResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Yumiko FujimuraDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Akiyoshi HirayamaInstitute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan.ORCID 0000-0002-0440-6820
Shinji FukudaInstitute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan.ORCID 0000-0001-5161-9880
Koji HaseDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Yun-Gi KimResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.ORCID 0000-0003-4251-1848
Keio University · JPUniversity of Tsukuba · JP

Funding

Food Science Institute FoundationJapan Agency for Medical Research and Development JP18gm6010004h0003Japan Agency for Medical Research and Development JP20gm1010009Japan Society for the Promotion of Science JP17H05068Japan Society for the Promotion of Science JP20H03490JST ERATO JPMJER1902Kaigen Pharma Co., Ltd.Mochida Memorial Foundation for Medical and Pharmaceutical ResearchNaito FoundationTakeda Science FoundationYakult Bio-Science Foundation
6 · The paper itself

Abstract

Metabolic syndrome (MetS) is a multifactorial chronic metabolic disorder that affects approximately one billion people worldwide. Recent studies have evaluated whether targeting the gut microbiota can prevent MetS. This study aimed to assess the ability of dietary fiber to control MetS by modulating gut microbiota composition. Sodium alginate (SA) is a seaweed-derived dietary fiber that suppresses high-fat diet (HFD)-induced MetS via an effect on the gut microbiota. We observed that SA supplementation significantly decreased body weight gain, cholesterol levels, and fat weight, while improving glucose tolerance in HFD-fed mice. SA changed the gut microbiota composition and significantly increased the abundance of

Indexed as

SeaweedAlginatesAnimalsCells, CulturedDietary FiberDiet, High-FatGastrointestinal MicrobiomeInflammationMetabolic SyndromeMiceMice, Inbred C57BLMonocytesAlginatesDietary Fibergut microbiotainflammatory monocytesmetabolic syndrome

Identifiers

PMID34444972
PMCPMC8401899
OpenAlexW3193910054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.