Evidence map›Paper›PMID 34444953›Full record

Observational studyNutrients2021

Vitamin D and Hashimoto's Thyroiditis: Observations from CROHT Biobank.

Maja Cvek, Dean Kaličanin, Ana Barić, Marko Vuletić, Ivana Gunjača, Vesela Torlak Lovrić, Veselin Škrabić, Ante Punda, Vesna Boraska Perica

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 47 citations in OpenAlex.

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  12. Association ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Maja CvekDepartment of Nuclear Medicine, University Hospital of Split, 21000 Split, Croatia.
Dean KaličaninDepartment of Medical Biology, School of Medicine, University of Split, 21000 Split, Croatia.ORCID 0000-0003-2348-3239
Ana BarićDepartment of Nuclear Medicine, University Hospital of Split, 21000 Split, Croatia.
Marko VuletićDepartment of Nuclear Medicine, University Hospital of Split, 21000 Split, Croatia.
Ivana GunjačaDepartment of Medical Biology, School of Medicine, University of Split, 21000 Split, Croatia.ORCID 0000-0002-7056-6443
Vesela Torlak LovrićDepartment of Nuclear Medicine, University Hospital of Split, 21000 Split, Croatia.
Veselin ŠkrabićDepartment of Pediatrics, University Hospital of Split, 21000 Split, Croatia.
Ante PundaDepartment of Nuclear Medicine, University Hospital of Split, 21000 Split, Croatia.
Vesna Boraska PericaDepartment of Medical Biology, School of Medicine, University of Split, 21000 Split, Croatia.ORCID 0000-0003-3999-1529
University of Split · HR

Funding

Hrvatska Zaklada za Znanost 4950
6 · The paper itself

Abstract

The aims of this study were to evaluate: (1) associations of vitamin D with the presence/severity of Hashimoto's thyroiditis (HT) and (2) correlations of vitamin D with thyroid-related phenotypes. Total 25(OH)D (vitamin D in the text) was measured from stored serum samples of 461 HT patients and 176 controls from a Croatian Biobank of HT patients (CROHT). (1) Vitamin D levels, and proportions of vitamin D deficiency, were compared between HT cases and controls. HT patients were additionally divided into two groups (MILD and OVERT) to take into account HT severity. (2) Correlations between vitamin D and 10 clinical phenotypes in all HT patients and two subgroups of HT patients were tested using the Spearman correlation test. Our analyses were adjusted for age, gender, BMI, smoking status and seasonality of blood sampling. (1) No significant differences in vitamin D levels, or proportions of vitamin D deficiency, were detected between HT patients of all disease stages and controls. However, a nominally significant difference in vitamin D levels between MILD and OVERT subgroups (OR = 1.038,

Indexed as

Severity of Illness IndexAdultBiological Specimen BanksBlood PressureCase-Control StudiesCroatiaFemaleHashimoto DiseaseHumansMaleMiddle AgedPhenotypeRetrospective StudiesSeasonsStatistics, NonparametricVitamin D25-hydroxyvitamin DVitamin DHashimoto’s thyroiditisthyroid autoimmunitythyroid stimulating hormone (TSH)thyrotropinvitamin D

Identifiers

PMID34444953
PMCPMC8401592
OpenAlexW3194969187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.