Evidence map›Paper›PMID 34444947›Full record

Observational studyNutrients2021

Daily Vegetables Intake and Response to COPD Rehabilitation. The Role of Oxidative Stress, Inflammation and DNA Damage.

Sara Ilari, Laura Vitiello, Patrizia Russo, Stefania Proietti, Mirta Milić, Carolina Muscoli, Vittorio Cardaci, Carlo Tomino, Gaia Bonassi, Stefano Bonassi

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  6. Observational
  7. Article
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  11. The Dietary Inflammatory Index (DII) and COPD: A Cross-Sectional Study from the NHANES.International journal of chronic obstructive pulmonary disease · 2025
    Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Sara IlariDepartment of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), University "Magna Graecia" of Catanzaro, 88201 Catanzaro, Italy.
Laura VitielloLaboratory of Flow Cytometry, IRCCS San Raffaele Roma, 00166 Rome, Italy.
Patrizia RussoClinical and Molecular Epidemiology, IRCCS San Raffaele Roma, 00166 Rome, Italy.
Stefania ProiettiClinical and Molecular Epidemiology, IRCCS San Raffaele Roma, 00166 Rome, Italy.
Mirta MilićMutagenesis Unit, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia.ORCID 0000-0002-9837-7185
Carolina MuscoliDepartment of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), University "Magna Graecia" of Catanzaro, 88201 Catanzaro, Italy.ORCID 0000-0002-1047-4467
Vittorio CardaciPulmonary Rehabilitation Unit, IRCCS San Raffaele Roma, 00166 Rome, Italy.
Carlo TominoScientific Direction, IRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0003-1823-2195
Gaia BonassiS.C. Medicina Fisica e Riabilitazione Ospedaliera, ASL4, Azienda Sanitaria Locale Chiavarese, 16034 Chiavari, Italy.
Stefano BonassiClinical and Molecular Epidemiology, IRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0003-3833-6717
Vita-Salute San Raffaele University · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITMagna Graecia University · ITASL Roma · ITInstitute for Medical Research and Occupational Health · HRIRCCS Ospedale San Raffaele · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a respiratory disease associated with airways inflammation and lung parenchyma fibrosis. The primary goals of COPD treatment are to reduce symptoms and risk of exacerbations, therefore pulmonary rehabilitation is considered the key component of managing COPD patients. Oxidative airway damage, inflammation and reduction of endogenous antioxidant enzymes are known to play a crucial role in the pathogenesis of COPD. Recently, also natural antioxidants have been considered as they play an important role in metabolism, DNA repair and fighting the effects of oxidative stress. In this paper we evaluated the response of 105 elderly COPD patients to pulmonary rehabilitation (PR), based on high or low vegetable consumption, by analyzing clinical parameters and biological measurements at baseline and after completion of the three weeks PR. We found that daily vegetable intake in normal diet, without any specific intervention, can increase the probability to successfully respond to rehabilitation (65.4% of responders ate vegetables daily vs. 40.0% of non-responders,

Indexed as

VegetablesAdministration, InhalationAdrenal Cortex HormonesAgedAged, 80 and overBronchodilator AgentsDiet, HealthyDiet SurveysDNA DamageEatingElder Nutritional Physiological PhenomenaFemaleHumansInflammationLungMaleAdrenal Cortex HormonesBronchodilator Agentschronic obstructive pulmonary disease (COPD)DNA damagegenomic instabilityinflammationoxidative stresspulmonary rehabilitationvegetables

Identifiers

PMID34444947
PMCPMC8398833
OpenAlexW3195171390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.