Evidence map›Paper›PMID 34444860›Full record

ArticleNutrients2021

Jujube Powder Enhances Cyclophosphamide Efficiency against Murine Colon Cancer by Enriching CD8

Huiren Zhuang, Nan Jing, Luoyang Wang, Guoqiang Jiang, Zheng Liu

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. The oncobiome; what, so what, now what?Microbiome research reports · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Effects ofFrontiers in nutrition · 2023
    Article
  12. The regulatory effects ofFood science & nutrition · 2022
    Article
  13. Therapeutic approaches to colorectal cancerFrontiers in microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Huiren ZhuangKey Lab of Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-1715-874X
Nan JingKey Lab of Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-0081-8473
Luoyang WangKey Lab of Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Guoqiang JiangKey Lab of Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Zheng LiuKey Lab of Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-0240-2121
Tsinghua University · CNQingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclophosphamide (CTX) is widely applied in cancer treatment. However, the outcome is often compromised by lymphopenia, myelosuppression, and gut dysbiosis. Here, we used jujube powder to enhance CTX efficiency through nurturing gut microbiota in order to facilitate favorable metabolisms. It was observed that the oral administration of jujube powder enriched CD8

Indexed as

FruitZiziphusAnimalsAntineoplastic Agents, AlkylatingBone MarrowCD8-Positive T-LymphocytesColonic NeoplasmsCombined Modality TherapyCyclophosphamideDisease Models, AnimalEosinophiliaGastrointestinal MicrobiomeLeukocyte CountLeukocytesMicePowdersAntineoplastic Agents, AlkylatingCyclophosphamidePowderschemotherapycyclophosphamidegut microbiotajujubemurine colon cancer

Identifiers

PMID34444860
PMCPMC8401958
OpenAlexW3187720415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.