Evidence map›Paper›PMID 34444835›Full record

ArticleNutrients2021

Milk Osteopontin for Gut, Immunity and Brain Development in Preterm Pigs.

Karoline Aasmul-Olsen, Nicole Lind Henriksen, Duc Ninh Nguyen, Anne Birgitte Heckmann, Thomas Thymann, Per Torp Sangild, Stine Brandt Bering

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Osteopontin: Its Properties, Recent Studies, and Potential Applications.International journal of molecular sciences · 2025
    Review
  2. Article
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  4. Skeletal consequences of preterm birth in pigs as a model for preterm infants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  5. Review
  6. Article
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  8. Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Karoline Aasmul-OlsenComparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.
Nicole Lind HenriksenComparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.ORCID 0000-0001-9202-1826
Duc Ninh NguyenComparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.ORCID 0000-0002-4997-555X
Anne Birgitte HeckmannArla Foods Ingredients Group P/S, Arla Foods Ingredients, 8260 Viby J, Denmark.
Thomas ThymannComparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.ORCID 0000-0001-7480-6064
Per Torp SangildComparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.
Stine Brandt BeringComparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.ORCID 0000-0002-6125-7892
University of Copenhagen · DKArla Foods (Denmark) · DK

Funding

Arla Foods Ingredients Group Bovine Milk Collaboration
6 · The paper itself

Abstract

Deficient levels of milk osteopontin (OPN) in infant formula may partly account for developmental differences between infants fed formula or maternal milk. We hypothesized that a milk diet supplemented with bovine milk OPN improves gut, immunity and brain development and tested this in a preterm pig model. Preterm pigs delivered by cesarean section (90% gestation) were fed raw bovine milk (CON,

Indexed as

AnimalsBody WeightBrainCattleCesarean SectionCognitionDietDietary SupplementsFemaleFood, FormulatedGastrointestinal TractImmunityIntestinal MucosaLymphocytesMilkOsteopontinOsteopontinbioactive milk proteinbrain developmentcognitionintestinal healthosteopontinpreterm neonatessystemic immunity

Identifiers

PMID34444835
PMCPMC8400468
OpenAlexW3187348567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.