Evidence map›Paper›PMID 34444820›Full record

Trial reportNutrients2021

Effects of Probiotic NVP-1704 on Mental Health and Sleep in Healthy Adults: An 8-Week Randomized, Double-Blind, Placebo-Controlled Trial.

Hyuk Joo Lee, Jung Kyung Hong, Jeon-Kyung Kim, Dong-Hyun Kim, Seok Won Jang, Seung-Won Han, In-Young Yoon

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 20 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 20 syntheses or guidelines pooled it, 143 citations in OpenAlex.

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  16. Nutraceuticals in Psychiatric Disorders: A Systematic Review.International journal of molecular sciences · 2024
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  20. Probiotics for the treatment of depression and its comorbidities: A systemic review.Frontiers in cellular and infection microbiology · 2023
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Hyuk Joo LeeDepartment of Psychiatry, Uijeongbu Eulji Medical Center, Eulji University, Gyeonggi 11759, Korea.ORCID 0000-0002-3569-9603
Jung Kyung HongDepartment of Psychiatry, Bundang Hospital, Seoul National University, Seongnam 13620, Korea.ORCID 0000-0002-1893-7868
Jeon-Kyung KimNeurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea.
Dong-Hyun KimNeurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea.
Seok Won JangPB Department, Navipharm Inc., Suwon 16209, Korea.ORCID 0000-0002-4049-6712
Seung-Won HanPB Department, Navipharm Inc., Suwon 16209, Korea.
In-Young YoonDepartment of Psychiatry, Bundang Hospital, Seoul National University, Seongnam 13620, Korea.
Kyung Hee University · KREulji University · KRSeoul National University · KRSeoul National University Bundang Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human gut microbiome is closely linked to mental health and sleep. We aimed to verify the efficacy and safety of probiotic NVP-1704, a mixture of

Indexed as

Mental HealthAdultAgedAnxietyBifidobacterium adolescentisBiomarkersDepressionDouble-Blind MethodFemaleGastrointestinal MicrobiomeHumansLimosilactobacillus reuteriMaleMiddle AgedProbioticsRNA, Ribosomal, 16SBiomarkersRNA, Ribosomal, 16Sanxietydepressiongut microbiomeprobioticsleep

Identifiers

PMID34444820
PMCPMC8398773
OpenAlexW3190494463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.