Evidence map›Paper›PMID 34444798›Full record

ArticleNutrients2021

Infants' First Solid Foods: Impact on Gut Microbiota Development in Two Intercontinental Cohorts.

Chiara-Maria Homann, Connor A J Rossel, Sara Dizzell, Liene Bervoets, Julia Simioni, Jenifer Li, Elizabeth Gunn, Michael G Surette, Russell J de Souza, Monique Mommers and 5 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07309536 (Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis), which is not on this map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07309536 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis (MUNCHIES): A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of New BrunswickRan2026 to 2027Enrolled40ConditionsGut Microbiome, Body Composition, Adherence, MetabolitesArmsMediterranean Diet Nutrition Program, Standard Diet Education Program
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
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  6. The Critical Period Microbiota Shape Brain Plasticity.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Chiara-Maria HomannDepartment of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Connor A J RosselDepartment of Medical Microbiology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-1919-7750
Sara DizzellDepartment of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Liene BervoetsDepartment of Medical Microbiology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands.
Julia SimioniDepartment of Obstetrics & Gynecology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Jenifer LiDepartment of Obstetrics & Gynecology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Elizabeth GunnDepartment of Pediatrics, McMaster University, Hamilton, ON L8S 4K1, Canada.
Michael G SuretteDepartment of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Russell J de SouzaDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0001-8945-513X
Monique MommersDepartment of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht University, 6229 ER Maastricht, The Netherlands.
Eileen K HuttonDepartment of Obstetrics & Gynecology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Katherine M MorrisonDepartment of Pediatrics, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0002-1737-256X
John PendersDepartment of Medical Microbiology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0001-9146-5919
Niels van BestDepartment of Medical Microbiology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0003-3577-7285
Jennifer C StearnsDepartment of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.ORCID 0000-0002-8603-6607
McMaster University · CAMaastricht University · NLPopulation Health Research Institute · CAMaastricht University Medical Centre · NL

Funding

CIHR IMG-143923CIHR MOP-136811Joint Programming Initiative A healthy diet for a healthy life 529051010
6 · The paper itself

Abstract

The introduction of solid foods is an important dietary event during infancy that causes profound shifts in the gut microbial composition towards a more adult-like state. Infant gut bacterial dynamics, especially in relation to nutritional intake remain understudied. Over 2 weeks surrounding the time of solid food introduction, the day-to-day dynamics in the gut microbiomes of 24 healthy, full-term infants from the Baby, Food & Mi and LucKi-Gut cohort studies were investigated in relation to their dietary intake. Microbial richness (observed species) and diversity (Shannon index) increased over time and were positively associated with dietary diversity. Microbial community structure (Bray-Curtis dissimilarity) was determined predominantly by individual and age (days). The extent of change in community structure in the introductory period was negatively associated with daily dietary diversity. High daily dietary diversity stabilized the gut microbiome. Bifidobacterial taxa were positively associated, while taxa of the genus

Indexed as

Gastrointestinal MicrobiomeInfant FoodBacteriaBiodiversityCohort StudiesDietEatingFecesFemaleHumansInfantInfant Nutritional Physiological PhenomenaMaleNetherlandsPhylogenyRNA, Ribosomal, 16SRNA, Ribosomal, 16S16S rRNAcomplementary foodsdietary diversitygut communityinfant gut microbiomeinfant nutritionintroduction to solidsmicrobial diversity

Identifiers

PMID34444798
PMCPMC8400337
OpenAlexW3191027227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.