Evidence map›Paper›PMID 34444770›Full record

ArticleNutrients2021

Testing and Prescribing Vitamin B12 in Swiss General Practice: A Survey among Physicians.

Katarina Bardheci, Levy Jäger, Lorenz Risch, Thomas Rosemann, Jakob M Burgstaller, Stefan Markun

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06669819 (Can Dietary Supplements be Linked to a Vegan Diet and Health Risk Modulation During Vegan Pregnancy, Infancy and Early Childhood), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06669819 recruitingnot on this mapstarted 2023, after this paper: background citation

Can Dietary Supplements be Linked to a Vegan Diet and Health Risk Modulation During Vegan Pregnancy, Infancy and Early Childhood

TypeobservationalSponsorWolfgang Huber-SchneiderRan2023 to 2025Enrolled1,000ConditionsVegan Diet, Pregnancy, Dietary Supplements, Childhood
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Katarina BardheciInstitute of Primary Care, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.
Levy JägerInstitute of Primary Care, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-7749-6759
Lorenz RischLabormedizinisches Zentrum Dr Risch AG, 9470 Buchs, Switzerland.ORCID 0000-0003-2692-6699
Thomas RosemannInstitute of Primary Care, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-6436-6306
Jakob M BurgstallerInstitute of Primary Care, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.
Stefan MarkunInstitute of Primary Care, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.
University of Zurich · CHLabormedizinische Zentrum Dr Risch (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Testing and prescribing vitamin B12 (also known as cobalamin) is increasing in Switzerland but substantial variation among general practitioners (GPs) with respect to testing has been noted. In this study, we aimed at exploring GPs' mindsets regarding vitamin B12 testing and prescribing. A cross-sectional study was conducted using an online survey distributed by e-mail to Swiss GPs. The questionnaire explored mindsets related to testing and prescribing vitamin B12 in specific clinical situations, as well as testing and prescribing strategies. The questionnaire was sent to 876 GPs and 390 GPs responded (44.5%). The most controversial domains for testing and prescribing vitamin B12 were idiopathic fatigue (57.4% and 43.4% of GPs agreed, respectively) and depressive symptoms (53.0% and 35.4% of GPs agreed, respectively). There was substantial variation among GPs with regard to testing strategies (89.5% of GPS used a serum cobalamin test, 71.3% of GPS used holotranscobalamin, and 27.6% of GPs used homocysteine or methylmalonic acid). Intramuscular injection was the predominantly prescribed route of application (median of 87.5% of the prescriptions). In this study, we focus on discordant mindsets that can be specifically targeted by using educational interventions, and research questions that still need answering specifically about the effectiveness of vitamin B12 for idiopathic fatigue.

Indexed as

General PracticeGeneral PractitionersAdolescentAdultAnemiaAttitude of Health PersonnelClinical Laboratory TechniquesCross-Sectional StudiesDepressionFatigueFemaleHumansMalePhysiciansPolyneuropathiesPractice Patterns, Physicians'Vitamin B 12anemiacobalamincognitivedepressiongeneral practitionersidiopathic fatiguelaboratory testingpolyneuropathysurveyvitamin B12

Identifiers

PMID34444770
PMCPMC8398177
OpenAlexW3186266108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.