Evidence map›Paper›PMID 34444753›Full record

ReviewNutrients2021

Possible Biochemical Processes Underlying the Positive Health Effects of Plant-Based Diets-A Narrative Review.

Zoltan Szabo, Viktor Koczka, Tamas Marosvolgyi, Eva Szabo, Eszter Frank, Eva Polyak, Kata Fekete, Attila Erdelyi, Zsofia Verzar, Maria Figler

Abstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  11. Calorie restriction and breast cancer treatment: a mini-review.Journal of molecular medicine (Berlin, Germany) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zoltan SzaboInstitute of Nutritional Sciences and Dietetics, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary.
Viktor KoczkaDepartment of Biochemistry and Medical Chemistry, Medical School, University of Pecs, 7624 Pecs, Hungary.ORCID 0000-0002-8118-0597
Tamas MarosvolgyiInstitute of Bioanalysis, Medical School, University of Pecs, 7624 Pecs, Hungary.ORCID 0000-0002-4244-5513
Eva SzaboDepartment of Biochemistry and Medical Chemistry, Medical School, University of Pecs, 7624 Pecs, Hungary.ORCID 0000-0002-3563-2492
Eszter FrankInstitute of Nutritional Sciences and Dietetics, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary.
Eva PolyakInstitute of Nutritional Sciences and Dietetics, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary.ORCID 0000-0002-3648-1614
Kata FeketeInstitute for Translational Medicine, Medical School, University of Pecs, 7624 Pecs, Hungary.
Attila ErdelyiInstitute of Health Insurance, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary.
Zsofia VerzarInstitute of Nutritional Sciences and Dietetics, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary.
Maria FiglerInstitute of Nutritional Sciences and Dietetics, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant-based diets are becoming more popular for many reasons, and epidemiological as well as clinical data also suggest that a well-balanced vegan diet can be adopted for the prevention, and in some cases, in the treatment of many diseases. In this narrative review, we provide an overview of the relationships between these diets and various conditions and their potential biochemical background. As whole plant foods are very rich in food-derived antioxidants and other phytochemicals, they have many positive physiological effects on different aspects of health. In the background of the beneficial health effects, several biochemical processes could stand, including the reduced formation of trimethylamine oxide (TMAO) or decreased serum insulin-like growth factor 1 (IGF-1) levels and altered signaling pathways such as mechanistic target of rapamycin (mTOR). In addition, the composition of plant-based diets may play a role in preventing lipotoxicity, avoiding N-glycolylneuraminic acid (Neu5Gc), and reducing foodborne endotoxin intake. In this article, we attempt to draw attention to the growing knowledge about these diets and provide starting points for further research.

Indexed as

Biochemical PhenomenaDietAnimalsAntioxidantsDiet, VeganEndotoxemiaHumansInsulin-Like Growth Factor IMethylaminesNeoplasmsSirolimusTOR Serine-Threonine KinasesVegansAntioxidantsIGF1 protein, humanInsulin-Like Growth Factor IMethylaminesSirolimusTOR Serine-Threonine KinasestrimethyloxamineantioxidantendotoxemiaIGF-1lipotoxicitymTORNeu5Gcplant-based dietTMAOvegan

Identifiers

PMID34444753
PMCPMC8398942

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.