ReviewNutrients2021
Whole-Grain Intake in the Mediterranean Diet and a Low Protein to Carbohydrates Ratio Can Help to Reduce Mortality from Cardiovascular Disease, Slow Down the Progression of Aging, and to Improve Lifespan: A Review.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Sustainable dietary recommendations for the Spanish population.European journal of clinical nutrition · 2026Pooled it
- Observational
- Transcriptomics Data Mining to Identify Novel Regulatory Genes of Iron Uptake in Drought-Stressed Wheat.International journal of molecular sciences · 2025Article
- The Complex Gene-Carbohydrate Interaction in Type 2 Diabetes: Between Current Knowledge and Future Perspectives.Nutrients · 2025Review
- Healthy ageing in older adults with cardiovascular disease.European heart journal · 2025Review
- Animal-derived foods, physical activities, and mild cognitive impairment among Chinese older adults: findings from CLHLS (2008-2018).BMC public health · 2025Article
- Dietary Carbohydrate Intake, Carbohydrate Quality, and Healthy Aging in Women.JAMA network open · 2025Article
- Article
- Editorial: Nutrition and mood disorders.Frontiers in nutrition · 2025Article
- Association between plant and animal protein and biological aging: findings from the UK Biobank.European journal of nutrition · 2024Article
- Impact of whole grain highland hull-less barley on the denaturing gradient gel electrophoresis profiles of gut microbial communities in rats fed high-fat diets.Microbiology spectrum · 2024Article
- 5-Heptadecylresorcinol Improves Aging-Associated Hepatic Fatty Acid Oxidation Dysfunction via Regulating Adipose Sirtuin 3.Nutrients · 2024Article
- Underrated aspects of a true Mediterranean diet: understanding traditional features for worldwide application of a "Planeterranean" diet.Journal of translational medicine · 2024Review
- Article
- Effects of Agricultural Intensification on Mediterranean Diets: A Narrative Review.Foods (Basel, Switzerland) · 2023Review
- Review
- Dietary Fiber Intake and Related Factors in Community-Based Iranian's Elderly.Medical journal of the Islamic Republic of Iran · 2023Article
- Effect of dietary protein intake on cognitive function in the elderly with chronic kidney disease: analysis of the National Health and Nutrition Examination Survey 2011-2014.Renal failure · 2023Article
- Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics.Advanced drug delivery reviews · 2022Review
- Association between the Mediterranean Diet Score and Healthy Life Expectancy: A Global Comparative Study.The journal of nutrition, health & aging · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increase in the aging population is a phenomenon all over the world. Maintaining good functional ability, good mental health, and cognitive function in the absence of severe disease and physical disability define successful aging. A healthy lifestyle in middle age predisposes successful aging. Longevity is the result of a multifactorial phenomenon, which involves feeding. Diets that emphasize fruit and vegetables, whole grains rather than refined grains, low-fat dairy, lean meats, fish, legumes, and nuts are inversely associated with mortality or to a lower risk of becoming frail among elderly subjects. A regular physical activity and a regular intake of whole grain derivatives together with the optimization of the protein/carbohydrate ratio in the diet, where the ratio is significantly less than 1 such as in the Mediterranean diet and the Okinawan diet, reduces the risk of developing aging-related diseases and increases healthy life expectancy. The purpose of our review was to analyze cohort and case-control studies that investigated the effects of cereals in the diet, especially whole grains and derivatives as well as the effects of a diet with a low protein-carbohydrate ratio on the progression of aging, mortality, and lifespan.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.