Evidence map›Paper›PMID 34444698›Full record

ArticleNutrients2021

Orphan Nuclear Receptor RORγ Modulates the Genome-Wide Binding of the Cholesterol Metabolic Genes during Mycotoxin-Induced Liver Injury.

Kaiqi Li, Hao Li, Kexin Zhang, Jinying Zhang, Ping Hu, Yanwei Li, Haotian Gu, Hao-Yu Liu, Zhangping Yang, Demin Cai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
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  6. Hepatic Anti-Oxidative GenesAntioxidants (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Can Red Yeast (Toxins · 2022
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kaiqi LiLaboratory of Animal Physiology and Molecular Nutrition, Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Hao LiLaboratory of Animal Physiology and Molecular Nutrition, Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Kexin ZhangLaboratory of Animal Physiology and Molecular Nutrition, Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Jinying ZhangLaboratory of Animal Physiology and Molecular Nutrition, Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Ping HuLaboratory of Animal Physiology and Molecular Nutrition, Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Yanwei LiLaboratory of Animal Physiology and Molecular Nutrition, Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Haotian GuLaboratory of Animal Physiology and Molecular Nutrition, Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Hao-Yu LiuLaboratory of Animal Physiology and Molecular Nutrition, Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Zhangping YangLaboratory of Animal Physiology and Molecular Nutrition, Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-5479-8447
Demin CaiLaboratory of Animal Physiology and Molecular Nutrition, Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0003-0500-5292
Yangzhou University · CN

Funding

Postgraduate Research & Practice Innovation Program of Yangzhou University X20200616Undergraduate Innovation and Entrepreneurship Training Program of Jiangsu Prov-ince 202011117068Y
6 · The paper itself

Abstract

Maintaining lipid homeostasis is crucial to liver function, the key organ that governs the whole-body energy metabolism. In contrast, lipid dysregulation has been implicated in mycotoxin-induced liver injury, by which the pathophysiological regulation and the molecular components involved remain elusive. Here we focused on the potential roles of orphan nuclear receptor (NR) RORγ in lipid programming, and aimed to explore its action on cholesterol regulation in the liver of mycotoxin-exposed piglets. We found that liver tissues were damaged in the mycotoxin-exposed piglets compared to the healthy controls, revealed by histological analysis, elevated seral ALT, AST and ALP levels, and increased caspase 3/7 activities. Consistent with the transcriptomic finding of down-regulated cholesterol metabolism, we demonstrated that both cholesterol contents and cholesterol biosynthesis/transformation gene expressions in the mycotoxin-exposed livers were reduced, including

Indexed as

AnimalsChemical and Drug Induced Liver Injury, ChronicCholesterolDisease Models, AnimalGene Expression RegulationHepatocytesHomeostasisLipid MetabolismLiverMycotoxinsNuclear Receptor Subfamily 1, Group F, Member 3SwineCholesterolMycotoxinsNuclear Receptor Subfamily 1, Group F, Member 3ChIP-seqcholesterol biosynthesisliver injurymycotoxinnuclear receptorRORγ

Identifiers

PMID34444698
PMCPMC8397974
OpenAlexW3186966241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.