ArticleInternational journal of environmental research and public health2021
Bayesian Sequential Monitoring of Single-Arm Trials: A Comparison of Futility Rules Based on Binary Data.
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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1 author.
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Abstract
In clinical trials, futility rules are widely used to monitor the study while it is in progress, with the aim of ensuring early termination if the experimental treatment is unlikely to provide the desired level of efficacy. In this paper, we focus on Bayesian strategies to perform interim analyses in single-arm trials based on a binary response variable. Designs that exploit both posterior and predictive probabilities are described and a slight modification of the futility rules is introduced when a fixed historical response rate is used, in order to add uncertainty in the efficacy probability of the standard treatment through the use of prior distributions. The stopping boundaries of the designs are compared under the same trial settings and simulation studies are performed to evaluate the operating characteristics when analogous procedures are used to calibrate the probability cut-offs of the different decision rules.
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Registered trials
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