ArticleInternational journal of environmental research and public health2021
Inverse Association between Serum 25-hydroxyvitamin D Levels and Risk of Suspected Non-Alcoholic Fatty Liver Disease in Obese Population.
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fatty liver index (FLI): more than a marker of hepatic steatosis.Journal of physiology and biochemistry · 2024Pooled it
- Serum vitamin D and lean non-alcoholic fatty liver disease: a nonlinear 'L-shaped' association in a national cross-sectional study.Annals of medicine · 2026Article
- Vitamin D Sufficiency Revisited: Evidence of a Dose-Response Effect for MASLD in Adults at Risk.Nutrients · 2026Article
- Association between use of vitamin and mineral supplement and non-alcoholic fatty liver disease in hypertensive adults.Scientific reports · 2023Article
- Vitamin D Supplementation in the Assessment of Cardiovascular Risk Factors in Overweight and Obese Children.Medical sciences (Basel, Switzerland) · 2022Observational
- Vitamin D Deficiency During Development Permanently Alters Liver Cell Composition and Function.Frontiers in endocrinology · 2022Article
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2 authors.
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Abstract
backgroundWorldwide, vitamin D deficiency is a public health issue and the prevalence of obesity and non-alcoholic fatty liver disease (NAFLD) are rapidly increasing. There are a limited number of studies assessing the association between serum levels of 25-hydroxyvitamin D (25(OH)D) and NAFLD risk in obese population.
objectiveWe evaluated the associations between serum 25(OH)D levels and risk of suspected NAFLD after stratification by obesity using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2014.
methodsThis study included 25,755 subjects without significant alcohol consumption for the serum alanine aminotransferase (ALT) and hepatic steatosis index (HSI) analyses (8922 subjects for the serum gamma-glutamyl transferase (GGT) and fatty liver index (FLI) analyses), based on a cross-sectional study design. Serum 25(OH)D levels were measured using a Gamma counter with radioimmunoassay. A survey logistic regression model was applied to estimate ORs and 95% CIs. Restricted cubic smoothing splines were applied to evaluate nonlinear associations.
resultsThe risk of suspected NAFLD was reduced per unit of natural log-transformed serum 25(OH)D concentration in obese individuals (OR [95% (CI)]; for ALT, 0.80 [0.67, 0.96]; for GGT, 0.70 [0.49, 0.99; for FLI, 0.68 [0.47, 1.01]; for HSI, 0.70 [0.56, 0.87]). The ORs [95% CI] of suspected NAFLD changed across the quartiles: for serum ALT, from 1.02 [0.85, 1.23] to 0.72 [0.59, 0.87]; for serum GGT, from 0.79 [0.56, 1.13] to 0.64 [0.44, 0.92]; for FLI, from 0.98 [0.67, 1.44] to 0.70 [0.48, 1.02]; and for HSI, from 0.91 [0.73, 1.14] to 0.65 [0.52, 0.81] with dose-response relationships (all
conclusionsThis study suggests that vitamin D sufficiency for public health should be emphasized in order to prevent adverse health effects in obese populations.
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