Evidence map›Paper›PMID 34444179›Full record

ArticleInternational journal of environmental research and public health2021

Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity.

Xuejie Wang, Carmen Villa, Yadira Dobarganes, Casilda Olveira, Rosa Girón, Marta García-Clemente, Luis Máiz, Oriol Sibila, Rafael Golpe, Rosario Menéndez and 8 more

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Inflammatory Phenotypes of Bronchiectasis.Journal of personalized medicine · 2025
    Review
  4. Review
  5. Article
  6. Observational
  7. Pathophysiology and genomics of bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Bronchiectasis, the Latest Eosinophilic Airway Disease: What About the Microbiome?American journal of respiratory and critical care medicine · 2022
    Article
  16. Article
  17. Article
  18. Observational
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xuejie WangLung Cancer and Muscle Research Group, Pulmonology Department, Hospital del Mar-IMIM, Parc de Salut Mar, 08003 Barcelona, Spain.
Carmen VillaRespiratory Department, Clínica Fuensanta, 28027 Madrid, Spain.
Yadira DobarganesRespiratory Department, Clínica Fuensanta, 28027 Madrid, Spain.
Casilda OlveiraRespiratory Department, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, 29010 Málaga, Spain.ORCID 0000-0002-6912-7400
Rosa GirónRespiratory Department, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, 28006 Madrid, Spain.
Marta García-ClementeRespiratory Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.
Luis MáizRespiratory Department, Hospital Ramon y Cajal, 28034 Madrid, Spain.
Oriol SibilaRespiratory Department, Hospital Clínic, 08036 Barcelona, Spain.
Rafael GolpeRespiratory Department, Hospital Lucus Augusti, 27003 Lugo, Spain.ORCID 0000-0002-3759-5322
Rosario MenéndezRespiratory Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.
Juan Rodríguez-LópezRespiratory Department, Hospital San Agustin, Avilés, 33401 Asturias, Spain.ORCID 0000-0003-0089-9768
Concepción PradosRespiratory Department, Hospital la Paz, 28046 Madrid, Spain.
Miguel Angel Martinez-GarcíaCentro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.ORCID 0000-0002-7321-1891
Juan Luis RodriguezRespiratory Department, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0003-0552-2484
David de la RosaRespiratory Department, Hospital Santa Creu I Sant Pau, 08041 Barcelona, Spain.ORCID 0000-0003-0753-1771
Xavier DuranScientific and Technical Department, Hospital del Mar-IMIM, 08003 Barcelona, Spain.
Jordi Garcia-OjalvoDepartment of Health and Experimental Sciences (CEXS), Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.ORCID 0000-0002-3716-7520
Esther BarreiroLung Cancer and Muscle Research Group, Pulmonology Department, Hospital del Mar-IMIM, Parc de Salut Mar, 08003 Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whether high blood eosinophil counts may define a better phenotype in bronchiectasis patients, as shown in chronic obstructive pulmonary disease (COPD), remains to be investigated. Differential phenotypic characteristics according to eosinophil counts were assessed using a biostatistical approach in a large cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 906 patients who met the inclusion criteria were clustered into two groups on the basis of their eosinophil levels. The potential differences according to the bronchiectasis severity index (BSI) score between two groups (Mann-Whitney

Indexed as

BronchiectasisPulmonary Disease, Chronic ObstructiveCluster AnalysisCohort StudiesEosinophilsHumansPhenotypeSeverity of Illness Indexbiostatistical analysesclinical outcomesdisease severity scoreseosinophil countsmultivariate analysesnon-cystic fibrosis bronchiectasisphenotypic clusters

Identifiers

PMID34444179
PMCPMC8392197

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.