Trial reportInternational journal of environmental research and public health2021
Effect of Platelet-Rich Fibrin Application on Non-Infectious Complications after Surgical Extraction of Impacted Mandibular Third Molars.
Trial report in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Platelet-rich fibrin after mandibular third molar extraction: a split-mouth and parallel-group stratified meta-analysis of randomized controlled trials (RCTs).Oral and maxillofacial surgery · 2026Pooled it
- Analgesic effects of platelet-rich fibrin (PRF): A systematic review.Periodontology 2000 · 2025Pooled it
- Efficacy of submucosal administration of tramadol on acute pain following third molar surgery: a systematic review and meta-analysis.Frontiers in oral health · 2024Pooled it
- Do blood concentrates influence inflammatory signs and symptoms after mandibular third molar surgery? A systematic review and network meta-analysis of randomized clinical trials.Clinical oral investigations · 2023Pooled it
- Clinical Indications to Germectomy in Pediatric Dentistry: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Evaluation of the usefulness of platelet-rich fibrin (PRF) in mandibular third molar surgery with 3D facial swelling analysis: a split-mouth randomized clinical trial.Head & face medicine · 2025Trial
- Effectiveness of platelet-rich fibrin in third molar extractions: a randomized controlled split-mouth study.Clinical oral investigations · 2024Trial
- Can concentrated growth factor prevent postoperative complications of impacted third molar surgery? A split-mouth randomized double-blind trial.Clinical oral investigations · 2024Trial
- Effect of concentrated growth factor (CGF) on postoperative sequel of completely impacted lower third molar extraction: a randomized controlled clinical study.BMC oral health · 2022Trial
- Efficacy of Leukocyte Platelet Rich Fibrin (L-PRF) Versus L-PRF with βeta Tri-calcium Phosphate (β-TCP) Bone Graft in Mandibular Impacted Third Molar Surgery: A Split-Mouth Double Blinded Randomized Control Study.Journal of dentistry (Shiraz, Iran) · 2026Article
- Performance of complementary therapies in controlling inflammatory signs, symptoms, and complications after lower third molar extraction: a bibliometric analysis of the top 100 most-cited articles.Acta cirurgica brasileira · 2026Review
- Bioactivity of dressings based on platelet-rich plasma and Platelet-rich fibrin for tissue regeneration in animal model.World journal of biological chemistry · 2025Article
- Factors affecting pain experience after lower third molar germectomy in teenagers-a clinical study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Article
- Blood concentrates for controlling postoperative complications from third molar surgeries: a scoping review.Acta cirurgica brasileira · 2025Article
- "Sticky Bone" Preparation Device: A Pilot Study on the Release of Cytokines and Growth Factors.Materials (Basel, Switzerland) · 2022Article
- Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw.Journal of clinical medicine · 2022Article
- The Growth Factors in Advanced Platelet-Rich Fibrin (A-PRF) Reduce Postoperative Complications after Mandibular Third Molar Odontectomy.International journal of environmental research and public health · 2021Article
- Knowledge of Dental Students from Croatia, Slovenia, and Bosnia and Herzegovina about Dental Care of Oncology Patients.Dentistry journal · 2021Article
- Comparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial.Journal of clinical medicine · 2021Article
- Submucosal Infiltration versus Intravenous Administration of Dexamethasone in Decreasing Post-operative Inflammatory Sequelae after Third Molar Surgery - A Comparative Study.Annals of maxillofacial surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the frequent development of non-infectious complications after surgical removal of the third lower impacted tooth, many techniques are used to reduce their severity. Among them is the technique of applying platelet-rich fibrin to the post-extraction alveolus. The study included 90 consecutively enrolled patients. Eligible patients were randomly assigned to two groups: patients with and without platelet-rich fibrin introduced into the postoperative alveolus. Pain, swelling, trismus, and temperature were evaluated after the procedure. Pain intensity was significantly higher in the control group than in the study group at 6 h, 1, and 3 days after surgery. PRF application did not significantly affect the intensity of swelling. Body temperature was significantly higher in the control group than the study group on day two after surgery. The trismus was significantly higher in the control group than in the study group at one, two, and seven days after surgery. Application of the PRF allows for a faster and less traumatic treatment process. It will enable for speedier recovery and return to active life and professional duties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.