Evidence map›Paper›PMID 34443815›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Targeting Intracellular Mycobacteria Using Nanosized Niosomes Loaded with Antibacterial Agents.

Yael Nicole Slavin, Kristina Ivanova, Wei-Lun Tang, Tzanko Tzanov, Shyh-Dar Li, Horacio Bach

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Biofilm · 2023
    Article
  4. International journal of molecular sciences · 2023
    Review
  5. Review
  6. Alternatives to Antibiotics againstAntibiotics (Basel, Switzerland) · 2022
    Review
  7. Lipid-Based Nanovesicular Drug Delivery Systems.Nanomaterials (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yael Nicole SlavinDivision of Infectious Diseases, Faculty of Medicine, The University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Kristina IvanovaGrup de Biotecnologia Molecular i Industrial, Department of Chemical Engineering, Universitat Politècnica de Catalunya, 08222 Terrassa, Spain.ORCID 0000-0001-9158-4088
Wei-Lun TangFaculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada.ORCID 0000-0002-9433-0398
Tzanko TzanovGrup de Biotecnologia Molecular i Industrial, Department of Chemical Engineering, Universitat Politècnica de Catalunya, 08222 Terrassa, Spain.ORCID 0000-0002-8568-1110
Shyh-Dar LiFaculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada.ORCID 0000-0002-1763-2667
Horacio BachDivision of Infectious Diseases, Faculty of Medicine, The University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
University of British Columbia · CAUniversitat Politècnica de Catalunya · ES

Funding

British Columbia Lung Association Grant-in-AidJoint Programming Initiative on Antimicrobial Resistance 01369-000
6 · The paper itself

Abstract

backgroundPathogenic intracellular mycobacteria are challenging to treat because of the waxy and complex cell wall characterizing the genus. Niosomes are vesicles with biomimetic cell membrane composition, which allow them to efficiently bind to the eukaryotic cells and deliver their cargo into the cytoplasm. The objective of this study was to develop a new platform based on niosomes loaded with antimicrobial agents to target intracellular mycobacteria. Nanoniosomes were fabricated and loaded with antibiotics and lignin-silver nanoparticles. The efficacy of these nanoniosomes was tested against the intracellular pathogen

results

conclusionsNanoniosomes improved drug efficacy while decreasing toxicity and should be considered for further testing in the treatment of intracellular pathogenic mycobacteria or as a new platform for precise intracellular delivery of drugs.

Indexed as

antibioticligninmacrophagemycobacteriananoparticleniosome

Identifiers

PMID34443815
PMCPMC8398725
OpenAlexW3187608952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.