Evidence map›Paper›PMID 34443714›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination.

Martin Pisárčik, Miloš Lukáč, Josef Jampílek, František Bilka, Andrea Bilková, Ľudmila Pašková, Ferdinand Devínsky, Renáta Horáková, Matěj Březina, Tomáš Opravil

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martin PisárčikDepartment of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, Slovakia.
Miloš LukáčDepartment of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, Slovakia.
Josef JampílekDepartment of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, SK-84215 Bratislava, Slovakia.
František BilkaDepartment of Cell and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, Slovakia.
Andrea BilkováDepartment of Cell and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, Slovakia.
Ľudmila PaškováDepartment of Cell and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, Slovakia.ORCID 0000-0001-8732-7054
Ferdinand DevínskyFaculty of Pharmacy, Comenius University, SK-83232 Bratislava, Slovakia.ORCID 0000-0002-8059-9994
Renáta HorákováComenius University, SK-81499 Bratislava, Slovakia.
Matěj BřezinaMaterials Research Centre, Faculty of Chemistry, University of Technology, CZ-61200 Brno, Czech Republic.
Tomáš OpravilMaterials Research Centre, Faculty of Chemistry, University of Technology, CZ-61200 Brno, Czech Republic.

Funding

Agentúra na Podporu Výskumu a Vývoja APVV-17-0373Vedecká Grantová Agentúra MŠVVaŠ SR a SAV 1/0054/19Vedecká Grantová Agentúra MŠVVaŠ SR a SAV 1/0686/21
6 · The paper itself

Abstract

Phosphorus-containing heterocyclic cationic surfactants alkyldimethylphenylphospholium bromides with the alkyl chain length 14 to 18 carbon atoms were used for the stabilization of silver nanodispersions. Zeta potential of silver nanodispersions ranges from +35 to +70 mV, which indicates the formation of stable silver nanoparticles (AgNPs). Long-chain heptadecyl and octadecyl homologs of the surfactants series provided the most intensive stabilizing effect to AgNPs, resulting in high positive zeta potential values and smaller diameter of AgNPs in the range 50-60 nm. A comparison with non-heterocyclic alkyltrimethylphosphonium surfactants of the same alkyl chain length showed better stability and more positive zeta potential values for silver nanodispersions stabilized with heterocyclic phospholium surfactants. Investigations of biological activity of phospholium-capped AgNPs are represented by the studies of antimicrobial activity and cytotoxicity. While cytotoxicity results revealed an increased level of HepG2 cell growth inhibition as compared with the cytotoxicity level of silver-free surfactant solutions, no enhanced antimicrobial action of phospholium-capped AgNPs against microbial pathogens was observed. The comparison of cytotoxicity of AgNPs stabilized with various non-heterocyclic ammonium and phosphonium surfactants shows that AgNPs capped with heterocyclic alkyldimethylphenylphospholium and non-heterocyclic triphenyl-substituted phosphonium surfactants have the highest cytotoxicity among silver nanodispersions stabilized by the series of ammonium and phosphonium surfactants.

Indexed as

cytotoxicitydynamic light scatteringHep G2 cellsphosphoniumsilver nanoparticleszeta potential

Identifiers

PMID34443714
PMCPMC8399434

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.