ReviewMolecules (Basel, Switzerland)2021
Protein Adducts and Protein Oxidation as Molecular Mechanisms of Flavonoid Bioactivity.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
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- Mechanistic Insight into the Antioxidant and Antimicrobial Activities of Palm Oil-Derived Biomaterials: Implications for Dental and Therapeutic Applications.International journal of molecular sciences · 2025Review
- Rosemary Extract Reduces Odor in Cats Through Nitrogen and Sulfur Metabolism by Gut Microbiota-Host Co-Modulation.Animals : an open access journal from MDPI · 2025Article
- Systematic Investigations of the Huperzine A-Producing Endophytic Fungi ofMolecules (Basel, Switzerland) · 2025Article
- Pharmacodynamics and safety in relation to dose and response of plant flavonoids in treatment of cancers.Inflammopharmacology · 2025Review
- Research Progress on the Mechanism of the Impact of Myofibrillar Protein Oxidation on the Flavor of Meat Products.Foods (Basel, Switzerland) · 2024Review
- Pilot-Scale Screening of Clinically Approved Drugs to Identify Uridine Insertion/Deletion RNA Editing Inhibitors inACS infectious diseases · 2024Article
- Glucose Metabolism-Modifying Natural Materials for Potential Feed Additive Development.Pharmaceutics · 2024Review
- Review
- Screening of MMolecules (Basel, Switzerland) · 2024Article
- Quercetin, a Flavonoid with Great Pharmacological Capacity.Molecules (Basel, Switzerland) · 2024Review
- Unraveling the Antioxidant Activity ofInternational journal of molecular sciences · 2023Article
- Protective Effect of Water-Soluble Acacetin Prodrug on APAP-Induced Acute Liver Injury Is Associated with Upregulation of PPARγ and Alleviation of ER Stress.International journal of molecular sciences · 2023Article
- Effect of Structural Differences in Naringenin, Prenylated Naringenin, and Their Derivatives on the Anti-Influenza Virus Activity and Cellular Uptake of Their Flavanones.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Excessive ConsumptionCells · 2022Article
- Oxidative Transformation of Dihydroflavonols and Flavan-3-ols by Anthocyanidin Synthase fromMolecules (Basel, Switzerland) · 2022Article
- Alkyne-Tagged Apigenin, a Chemical Tool to Navigate Potential Targets of Flavonoid Anti-Dengue Leads.Molecules (Basel, Switzerland) · 2021Article
- Perspective on Improving the Relevance, Rigor, and Reproducibility of Botanical Clinical Trials: Lessons Learned From Turmeric Trials.Frontiers in nutrition · 2021Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are tens of thousands of scientific papers about flavonoids and their impacts on human health. However, despite the vast amount of energy that has been put toward studying these compounds, a unified molecular mechanism that explains their bioactivity remains elusive. One contributing factor to the absence of a general mechanistic explanation of their bioactivity is the complexity of flavonoid chemistry in aqueous solutions at neutral pH. Flavonoids have acidic protons, are redox active, and frequently auto-oxidize to produce an array of degradation products including electrophilic quinones. Flavonoids are also known to interact with specificity and high affinity with a variety of proteins, and there is evidence that some of these interactions may be covalent. This review summarizes the mechanisms of flavonoid oxidation in aqueous solutions at neutral pH and proposes the formation of protein-flavonoid adducts or flavonoid-induced protein oxidation as putative mechanisms of flavonoid bioactivity in cells. Nucleophilic residues in proteins may be able to form covalent bonds with flavonoid quinones; alternatively, specific amino acid residues such as cysteine, methionine, or tyrosine in proteins could be oxidized by flavonoids. In either case, these protein-flavonoid interactions would likely occur at specific binding sites and the formation of these types of products could effectively explain how flavonoids modify proteins in cells to induce downstream biochemical and cellular changes.
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