Evidence map›Paper›PMID 34443666›Full record

ArticleMolecules (Basel, Switzerland)2021

Nucleus-Independent Chemical Shift (NICS) as a Criterion for the Design of New Antifungal Benzofuranones.

María de Los Ángeles Zermeño-Macías, Marco Martín González-Chávez, Francisco Méndez, Arlette Richaud, Rodolfo González-Chávez, Luis Enrique Ojeda-Fuentes, Perla Del Carmen Niño-Moreno, Roberto Martínez

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

María de Los Ángeles Zermeño-MacíasFacultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava No. 6 Zona Universitaria, San Luis Potosí 78210, Mexico.
Marco Martín González-ChávezFacultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava No. 6 Zona Universitaria, San Luis Potosí 78210, Mexico.
Francisco MéndezDepartamento de Química, División de Ciencias Biológicas e Ingeniería, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Ciudad de México 09340, Mexico.ORCID 0000-0002-0555-1528
Arlette RichaudDepartamento de Química, División de Ciencias Biológicas e Ingeniería, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Ciudad de México 09340, Mexico.ORCID 0000-0003-1682-8446
Rodolfo González-ChávezFacultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava No. 6 Zona Universitaria, San Luis Potosí 78210, Mexico.
Luis Enrique Ojeda-FuentesFacultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava No. 6 Zona Universitaria, San Luis Potosí 78210, Mexico.
Perla Del Carmen Niño-MorenoCentro de Investigación en Ciencias de la Salud y Biomedicina (CICSaB), UASLP. Av. Paseo de los Derechos Humanos No. 300, Lomas de San Luis, San Luis Potosí 78210, Mexico.
Roberto MartínezInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior de Ciudad Universitaria, Ciudad de México 04510, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The assertion made by Wu et al. that aromaticity may have considerable implications for molecular design motivated us to use nucleus-independent chemical shifts (NICS) as an aromaticity criterion to evaluate the antifungal activity of two series of indol-4-ones. A linear regression analysis of NICS and antifungal activity showed that both tested variables were significantly related (

Indexed as

Antifungal AgentsAspergillus nigerBenzofuransCandidaFungiHumansMicrobial Sensitivity TestsMolecular StructurePichiaPolycyclic Aromatic HydrocarbonsAntifungal AgentsBenzofuransPolycyclic Aromatic Hydrocarbonsantifungal activityaromaticitybenzofuran-4-oneNICSquantitative structure–activity relationship

Identifiers

PMID34443666
PMCPMC8401487

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.