Studies of Interaction Mechanism between Pyrido [3,4-

Cheng Xing, Xiaoping Zhou, Chengjuan Chen, Wei Sun, Qingchuan Zheng, Di Liang

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Combined 3D-QSAR, molecular docking and dynamics simulations studies to model and design TTK inhibitors.Frontiers in chemistry · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cheng XingSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.

Xiaoping ZhouSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.

Chengjuan ChenSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.

Wei SunSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.

Qingchuan ZhengLaboratory of Theoretical and Computational Chemistry, Jilin University, Changchun 130023, China.

Di LiangSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monopolar spindle 1 (Mps1), a dual-specific kinase, is related to the proper execution of chromosome biorientation and mitotic checkpoint signaling. The overexpression of Mps1 promotes the occurrence of cancer or the survival of aneuploid cancer cells, in other words, the reduction of Mps1 will severely reduce the viability of human cancer cells. Therefore, Mps1 is a potential target for cancer treatment. Recently, a series of novel pyrido [3,4-

Indexed as

Catalytic DomainCell Cycle ProteinsCrystallography, X-RayHumansMolecular Docking SimulationMolecular Dynamics SimulationProtein Kinase InhibitorsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesPyrimidinesCell Cycle ProteinsProtein Kinase InhibitorsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesPyrimidinesTTK protein, humandrug designmolecular dockingmolecular dynamics simulationsMonopolar spindle 1pyrido [3,4-d] pyrimidine

Identifiers

PMID34443663

DOI10.3390/molecules26165075

PMCPMC8401005

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.