Evidence map›Paper›PMID 34443658›Full record

ArticleMolecules (Basel, Switzerland)2021

Determination of the Absolute Configuration of Bioactive Indole-Containing Pyrazino[2,1-

Solida Long, Izadora L Furlani, Juliana M de Oliveira, Diana I S P Resende, Artur M S Silva, Luís Gales, José A Pereira, Anake Kijjoa, Quezia B Cass, Regina V Oliveira and 2 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Indole-Containing Pyrazino[2,1-ACS medicinal chemistry letters · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Solida LongLQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.ORCID 0000-0002-3142-4864
Izadora L FurlaniSEPARARE-Núcleo de Pesquisa em Cromatografia, Departamento de Química, Universidade Federal de São Carlos, Rodovia Washington Luiz, km 235, São Carlos 13565-905, Brazil.ORCID 0000-0002-2745-7612
Juliana M de OliveiraSEPARARE-Núcleo de Pesquisa em Cromatografia, Departamento de Química, Universidade Federal de São Carlos, Rodovia Washington Luiz, km 235, São Carlos 13565-905, Brazil.
Diana I S P ResendeLQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.ORCID 0000-0002-4077-6060
Artur M S SilvaLAQV-REQUIMTE-Departamento de Química, Universidade de Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0003-2861-8286
Luís GalesICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.
José A PereiraICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.ORCID 0000-0003-2604-2375
Anake KijjoaCIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos S/N, Matosinhos, 4450-208 Porto, Portugal.ORCID 0000-0002-3321-1061
Quezia B CassSEPARARE-Núcleo de Pesquisa em Cromatografia, Departamento de Química, Universidade Federal de São Carlos, Rodovia Washington Luiz, km 235, São Carlos 13565-905, Brazil.ORCID 0000-0002-6550-1194
Regina V OliveiraSEPARARE-Núcleo de Pesquisa em Cromatografia, Departamento de Química, Universidade Federal de São Carlos, Rodovia Washington Luiz, km 235, São Carlos 13565-905, Brazil.
Emília SousaLQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.ORCID 0000-0002-5397-4672
Madalena M M PintoLQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.ORCID 0000-0002-4676-1409

Funding

Fundação para a Ciência e a Tecnologia CIIMAR UIDB/04423/2020 , PTDC/SAU-PUB/28736/2017 (reference POCI-01-0145-FEDER-028736)
6 · The paper itself

Abstract

In recent decades, fungi-derived naturally occurring quinazolines have emerged as potential drug candidates. Nevertheless, most studies are conducted for bioactivity assays, and little is known about their absorption, distribution, metabolism, and elimination (ADME) properties. To perform metabolic studies, the synthesis of the naturally occurring quinazolinone, fiscalin B (

Indexed as

Anti-Bacterial AgentsBiological ProductsChromatography, High Pressure LiquidCircular DichroismCrystallography, X-RayFungiHumansIndolesMass SpectrometryMetabolomeMolecular StructurePyrazinesQuinazolinesStereoisomerismAnti-Bacterial AgentsBiological ProductsindoleIndolesPyrazinesQuinazolinesECDenantioselectivitygram-scale synthesisin vitro metabolismX-ray crystallography

Identifiers

PMID34443658
PMCPMC8398919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.