Evidence map›Paper›PMID 34443620›Full record

ArticleMolecules (Basel, Switzerland)2021

Selective Binding and Redox-Activity on Parallel G-Quadruplexes by Pegylated Naphthalene Diimide-Copper Complexes.

Valentina Pirota, Enrico Lunghi, Alessandra Benassi, Emmanuele Crespan, Mauro Freccero, Filippo Doria

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Valentina PirotaDepartment of Chemistry, University of Pavia, Via Taramelli 10, 27100 Pavia, Italy.ORCID 0000-0002-6683-1726
Enrico LunghiDepartment of Chemistry, University of Pavia, Via Taramelli 10, 27100 Pavia, Italy.
Alessandra BenassiDepartment of Chemistry, University of Pavia, Via Taramelli 10, 27100 Pavia, Italy.
Emmanuele CrespanInstitute of Molecular Genetics IGM-CNR "Luigi Luca Cavalli-Sforza", Via Abbiategrasso 207, 27100 Pavia, Italy.ORCID 0000-0003-0597-6929
Mauro FrecceroDepartment of Chemistry, University of Pavia, Via Taramelli 10, 27100 Pavia, Italy.ORCID 0000-0002-7438-1526
Filippo DoriaDepartment of Chemistry, University of Pavia, Via Taramelli 10, 27100 Pavia, Italy.ORCID 0000-0002-1308-1060
University of Pavia · ITIstituto di Genetica Molecolare · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G-quadruplexes (G4s) are higher-order supramolecular structures, biologically important in the regulation of many key processes. Among all, the recent discoveries relating to RNA-G4s, including their potential involvement as antiviral targets against COVID-19, have triggered the ever-increasing need to develop selective molecules able to interact with parallel G4s. Naphthalene diimides (NDIs) are widely exploited as G4 ligands, being able to induce and strongly stabilize these structures. Sometimes, a reversible NDI-G4 interaction is also associated with an irreversible one, due to the cleavage and/or modification of G4s by functional-NDIs. This is the case of

Indexed as

G-QuadruplexesBinding SitesCoordination ComplexesCopperDEETImidesLigandsNaphthalenesOxidation-ReductionPolyethylene GlycolsStructure-Activity RelationshipCoordination ComplexesCopperDEETImidesLigandsnaphthalenenaphthalenediimideNaphthalenesPolyethylene Glycolscopper-complexescopper redox activityG-quadruplexG-quadruplex-selective ligandnaphthalene diimide

Identifiers

PMID34443620
PMCPMC8397950
OpenAlexW3193914726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.