Evidence map›Paper›PMID 34443605›Full record

ArticleMolecules (Basel, Switzerland)2021

Anti-Cancer Activity and Phenolic Content of Extracts Derived from Cypriot Carob (

Gregoria Gregoriou, Christiana M Neophytou, Alexandru Vasincu, Yiota Gregoriou, Haria Hadjipakkou, Eftychia Pinakoulaki, Marios C Christodoulou, Georgia D Ioannou, Ioannis J Stavrou, Atalanti Christou and 5 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Carob (Reviews on recent clinical trials · 2024
    Pooled it
  3. Article
  4. Review
  5. Phenolic metabolites fromFrontiers in pharmacology · 2026
    Article
  6. Development of Calcium Alginate Hydrogels withGels (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Antioxidant and Anticancer Activity ofLife (Basel, Switzerland) · 2024
    Article
  17. Exploring Carob (Plants (Basel, Switzerland) · 2023
    Review
  18. Biological Activities ofInternational journal of molecular sciences · 2023
    Article
  19. Exploring the Multi-Faceted Potential of Carob (Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Gregoria GregoriouDepartment of Biological Sciences, University of Cyprus, Nicosia 1678, Cyprus.
Christiana M NeophytouDepartment of Biological Sciences, University of Cyprus, Nicosia 1678, Cyprus.ORCID 0000-0003-0823-2888
Alexandru VasincuDepartment of Pharmacodynamics and Clinical Pharmacy, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iaşi, Romania.ORCID 0000-0002-3948-6496
Yiota GregoriouDepartment of Biological Sciences, University of Cyprus, Nicosia 1678, Cyprus.
Haria HadjipakkouDepartment of Chemistry, University of Cyprus, Nicosia 1678, Cyprus.
Eftychia PinakoulakiDepartment of Chemistry, University of Cyprus, Nicosia 1678, Cyprus.
Marios C ChristodoulouDepartment of Chemistry, University of Cyprus, Nicosia 1678, Cyprus.ORCID 0000-0003-1940-6345
Georgia D IoannouDepartment of Chemistry, University of Cyprus, Nicosia 1678, Cyprus.
Ioannis J StavrouDepartment of Chemistry, University of Cyprus, Nicosia 1678, Cyprus.
Atalanti ChristouDepartment of Chemistry, University of Cyprus, Nicosia 1678, Cyprus.
Constantina P Kapnissi-ChristodoulouDepartment of Chemistry, University of Cyprus, Nicosia 1678, Cyprus.
Siegfried AignerInstitute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck (CMBI), Center for Chemistry and Biomedicine, University of Innsbruck, 6020 Innsbruck, Austria.
Hermann StuppnerInstitute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck (CMBI), Center for Chemistry and Biomedicine, University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-8862-0201
Antonis KakasDepartment of Computer Science, University of Cyprus, Nicosia 1678, Cyprus.
Andreas I ConstantinouDepartment of Biological Sciences, University of Cyprus, Nicosia 1678, Cyprus.
University of Cyprus · CYEuropean University Cyprus · CYUniversität Innsbruck · ATGrigore T. Popa University of Medicine and Pharmacy · RO

Funding

Research and Innovation Foundation Cyprus BlackGold INTEGRATED/0916/0019
6 · The paper itself

Abstract

Extracts derived from the

Indexed as

AntioxidantsApoptosisCell ProliferationPhenolsPlant ExtractsSolventsAntineoplastic Agents, PhytogenicCell Line, TumorFabaceaeHumansPolyphenolsAntineoplastic Agents, PhytogenicAntioxidantsPhenolsPlant ExtractsPolyphenolsSolventsanti-oxidant activityantiproliferative capacityapoptosiscarobschemopreventionkaempferolLC-MSmyricetinnaringeninpolyphenols

Identifiers

PMID34443605
PMCPMC8401790
OpenAlexW3194250048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.