Evidence map›Paper›PMID 34443583›Full record

ReviewMolecules (Basel, Switzerland)2021

Substituted Pyrazoles and Their Heteroannulated Analogs-Recent Syntheses and Biological Activities.

Mohamed Ramadan, Ashraf A Aly, Lamiaa E Abd El-Haleem, Mohammed B Alshammari, Stefan Bräse

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Pyrazole Derivatives as Selective COX-2 Inhibitors: An Updated Review.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2026
    Review
  5. Anticancer Activity ofBiomolecules · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Synthesis,Journal of enzyme inhibition and medicinal chemistry · 2023
    Article
  12. Synthesis of 5,6-Dihydropyrazolo[5,1-Molecules (Basel, Switzerland) · 2023
    Article
  13. Article
  14. Frontiers in bioengineering and biotechnology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohamed RamadanOrganic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assuit 71524, Egypt.ORCID 0000-0002-7975-3421
Ashraf A AlyChemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt.ORCID 0000-0002-0314-3408
Lamiaa E Abd El-HaleemChemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt.
Mohammed B AlshammariChemistry Department, College of Sciences and Humanities, Prince Sattam Bin Abdulaziz University, P.O. Box 83, Al-Kharij 11942, Saudi Arabia.ORCID 0000-0001-9687-8747
Stefan BräseInstitute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives. Therefore, we focused our attention on recent topics, up until 2020, for the synthesis of pyrazoles, their heteroannulated derivatives, and their applications as biologically active moieties. Moreover, we focused on traditional procedures used in the synthesis of pyrazoles.

Indexed as

PyrazolesAnimalsAntineoplastic AgentsHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsPyrazolesbiological activityheteroannulatedpyrazolereactionssynthesis

Identifiers

PMID34443583
PMCPMC8401439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.