Evidence map›Paper›PMID 34443550›Full record

ArticleMolecules (Basel, Switzerland)2021

Novel Anti-Melanogenic Compounds, (

Heejeong Choi, Il Young Ryu, Inkyu Choi, Sultan Ullah, Hee Jin Jung, Yujin Park, Yeongmu Jeong, YeJi Hwang, Sojeong Hong, In-Soo Yoon and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Heterocyclic Compounds as Synthetic Tyrosinase Inhibitors: Recent Advances.International journal of molecular sciences · 2023
    Review
  4. Design and Synthesis of (Antioxidants (Basel, Switzerland) · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Heejeong ChoiLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Il Young RyuLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Inkyu ChoiLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Sultan UllahDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA.ORCID 0000-0002-6972-3157
Hee Jin JungLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Yujin ParkLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Yeongmu JeongLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.
YeJi HwangLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Sojeong HongLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.
In-Soo YoonLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.ORCID 0000-0002-0997-5723
Hwayoung YunLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.ORCID 0000-0003-1414-6169
Min-Soo KimLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Jin-Wook YooLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.ORCID 0000-0001-5216-5518
Yunjin JungLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Pusoon ChunCollege of Pharmacy, Inje University, Gyeongnam, Gimhae 50834, Korea.
Hyung Ryong MoonLaboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, Korea.ORCID 0000-0003-1119-7112
Pusan National University · KRInje University · KRScripps Research Institute · US

Funding

Inje University 20210001
6 · The paper itself

Abstract

To confirm that the β-phenyl-α,β-unsaturated thiocarbonyl (PUSTC) scaffold, similar to the β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold, acts as a core inhibitory structure for tyrosinase, twelve (

Indexed as

Enzyme InhibitorsMelaninsMolecular Docking SimulationMonophenol MonooxygenaseAgaricalesAnimalsCell Line, TumorHumansMelanoma, ExperimentalMiceMolecular StructurePyronesStructure-Activity RelationshipThiazolidinesEnzyme Inhibitorskojic acidMelaninsMonophenol MonooxygenasePyronesThiazolidinesanti-melanogenic effectdocking simulationPUSTC scaffoldtyrosinase

Identifiers

PMID34443550
PMCPMC8400311
OpenAlexW3195483805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.