Evidence map›Paper›PMID 34443490›Full record

ArticleMolecules (Basel, Switzerland)2021

Antitumor Mechanism of Hydroxycamptothecin via the Metabolic Perturbation of Ribonucleotide and Deoxyribonucleotide in Human Colorectal Carcinoma Cells.

Yan Li, Wendi Luo, Huixia Zhang, Caiyun Wang, Caiyuan Yu, Zhihong Jiang, Wei Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Functionalized Carbon Dots With Intrinsic Wnt/International journal of nanomedicine · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yan LiState Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China.
Wendi LuoState Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China.
Huixia ZhangState Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China.
Caiyun WangState Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China.
Caiyuan YuFaculty of Agroforestry and Medicine, The Open University of China, Beijing 100039, China.
Zhihong JiangState Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China.ORCID 0000-0002-7956-2481
Wei ZhangState Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China.
Macau University of Science and Technology · MOOpen University of China · CN

Funding

Science and Technology Development Fund, Macau SAR 0023/2019/AKPScience and Technology Development Fund, Macau SAR 0052/2018/A2Science and Technology Development Fund, Macau SAR 0077/2019/A2
6 · The paper itself

Abstract

Hydroxycamptothecin (SN38) is a natural plant extract isolated from

Indexed as

Antineoplastic Agents, PhytogenicCamptothecinCell Cycle CheckpointsCell Cycle ProteinsCell SurvivalColorectal NeoplasmsDNADNA DamageHCT116 CellsHumansIrinotecanRibonucleoside Diphosphate ReductaseRibonucleotide ReductasesRibonucleotidesAntineoplastic Agents, PhytogenicCamptothecinCell Cycle ProteinsDNAhydroxycamptothecinumIrinotecanRibonucleoside Diphosphate Reductaseribonucleotide reductase M2Ribonucleotide ReductasesRibonucleotidesRRM1 protein, humanRRM2B protein, humandeoxyribonucleotidehydroxycamptothecinperturbationribonucleotide

Identifiers

PMID34443490
PMCPMC8398164
OpenAlexW3193571373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.