ArticleMolecules (Basel, Switzerland)2021
Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors.
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Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Inhibitors Targeting SARS-CoV-2 Papain-Like Protease: Screening, Design, Synthesis, and Biological Evaluation.ChemMedChem · 2026Article
- Phospholipases ABiomolecules · 2025Review
- Screening of Medicines for Malaria Venture Open Boxes Identifies Potent SARS-CoV‑2 Papain-like Protease (PLACS omega · 2025Article
- Antiviral Activity of Liposomes Containing Natural Compounds Against CHIKV.Pharmaceutics · 2025Article
- An in-depth exploration of snake venom-derived molecules for drug discovery in advancing antiviral therapeutics.Heliyon · 2024Review
- The Synthetic Peptide GA-Hecate and Its Analogs Inhibit Multiple Steps of the Chikungunya Virus Infection Cycle In Vitro.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Development of New Leishmanicidal Compounds via Bioconjugation of Antimicrobial Peptides and Antileishmanial Guanidines.ACS omega · 2023Article
- Antiviral Evaluation of New Synthetic Bioconjugates Based on GA-Hecate: A New Class of Antivirals Targeting Different Steps of Zika Virus Replication.Molecules (Basel, Switzerland) · 2023Article
- The Dimeric Peptide (KKYRYHLKPF)Viruses · 2023Article
- The evaluation ofJournal of drug delivery science and technology · 2023Article
- Review
- [Analysis and identification of suspected snake venom samples using nano-ultra-high performance liquid chromatography-high resolution mass spectrometry].Se pu = Chinese journal of chromatography · 2023Article
- Effects of Dimerization, Dendrimerization, and Chirality in p-BthTX-I Peptide Analogs on the Antibacterial Activity and Enzymatic Inhibition of the SARS-CoV-2 PLPharmaceutics · 2023Article
- A snake venom-analog peptide that inhibits SARS-CoV-2 and papain-like protease displays antithrombotic activity in mice arterial thrombosis model, without interfering with bleeding time.Thrombosis journal · 2023Article
- Celastrol: A lead compound that inhibits SARS-CoV-2 replication, the activity of viral and human cysteine proteases, and virus-induced IL-6 secretion.Drug development research · 2022Article
- Nano-multilamellar lipid vesicles promote the induction of SARS-CoV-2 immune responses by a protein-based vaccine formulation.Nanomedicine : nanotechnology, biology, and medicine · 2022Article
- Antiviral Effects of Animal Toxins: Is There a Way to Drugs?International journal of molecular sciences · 2022Review
- SARS-COV-2 Coronavirus Papain-like Protease PLpro as an Antiviral Target for Inhibitors of Active Site and Protein-Protein Interactions.Biophysics · 2022Article
- The chemistry of snake venom and its medicinal potential.Nature reviews. Chemistry · 2022Review
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 1 country.
Marjorie C L C FreireSão Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.ORCID 0000-0001-7734-5144
Gabriela D NoskeSão Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.
Natália V BitencourtDepartment of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil.
Paulo R S SanchesDepartment of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil.
Norival A Santos-FilhoDepartment of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil.ORCID 0000-0002-0344-6900
Victor O GawriljukSão Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.
Eduardo P de SouzaDepartment of Genetics and Evolution, Federal University of São Carlos, Rodovia Washington Luís km 235, São Carlos 13565-905, SP, Brazil.ORCID 0000-0002-2013-0115
Victor H R NogueiraSão Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.ORCID 0000-0003-0755-2521
Mariana O de GodoySão Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.
Aline M NakamuraSão Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.
Rafaela S FernandesSão Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.ORCID 0000-0002-4332-0448
Andre S GodoySão Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.ORCID 0000-0002-0613-9164
Maria A JulianoThe Sao Paulo School of Medicine, Federal University of São Paulo, Rua Três de Maio, 100, São Paulo 04044-020, SP, Brazil.
Bianca M PeresDepartment of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, São Paulo 05508-900, SP, Brazil.ORCID 0000-0001-8189-9799
Cecília G BarbosaDepartment of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, São Paulo 05508-900, SP, Brazil.
Carolina B MoraesDepartment of Pharmaceutical Sciences, Federal University of São Paulo, Rua São Nicolau, 210, Diadema 09913-030, SP, Brazil.ORCID 0000-0002-0689-2770
Lucio H G Freitas-JuniorDepartment of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, São Paulo 05508-900, SP, Brazil.
Eduardo M CilliDepartment of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil.ORCID 0000-0002-4767-0904
Rafael V C GuidoSão Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.ORCID 0000-0002-7187-0818
Glaucius OlivaSão Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.ORCID 0000-0003-2719-0302
Universidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BRUniversidade Federal de São Paulo · BRUniversidade Federal de São Carlos · BR
Funding
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Finance Code 001 and grant 23038.014330/2020-11Sao Paulo Research Foundation - FAPESP 2013/07600-3, 2020/04602-9, 2018/13588-0, and 2020/05761-3
Abstract
The COVID-19 outbreak has rapidly spread on a global scale, affecting the economy and public health systems throughout the world. In recent years, peptide-based therapeutics have been widely studied and developed to treat infectious diseases, including viral infections. Herein, the antiviral effects of the lysine linked dimer des-Cys
Indexed as
Antiviral AgentsPeptidesSARS-CoV-2Chlorocebus aethiopsCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesCOVID-19COVID-19 Drug TreatmentHumansMolecular Docking SimulationProtease InhibitorsVero CellsAntiviral AgentsCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesPeptidesProtease InhibitorsCOVID-19inhibitorsPapain-like proteasepeptidesSARS-CoV-2
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.