Evidence map›Paper›PMID 34443477›Full record

ArticleMolecules (Basel, Switzerland)2021

Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions.

Jeremy Gleaton, Ryan W Curtis, Jean Chmielewski

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jeremy GleatonDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
Ryan W CurtisDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
Jean ChmielewskiDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, the hierarchical assembly of a collagen mimetic peptide (CMP) displaying four bipyridine moieties is described. The CMP was capable of forming triple helices followed by self-assembly into disks and domes. Treatment of these disks and domes with metal ions such as Fe(II), Cu(II), Zn(II), Co(II), and Ru(III) triggered the formation of microcages, and micron-sized cup-like structures. Mechanistic studies suggest that the formation of the microcages proceeds from the disks and domes in a metal-dependent fashion. Fluorescently-labeled dextrans were encapsulated within the cages and displayed a time-dependent release using thermal conditions.

Indexed as

Biomimetic MaterialsCollagenDextransIonsLigandsMetalsMolecular StructurePeptidesCollagenDextransIonsLigandsMetalsPeptidescollagen mimetic peptideencapsulationhierarchical self-assemblythermal release

Identifiers

PMID34443477
PMCPMC8401520

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.