Evidence map›Paper›PMID 34443427›Full record

ArticleMolecules (Basel, Switzerland)2021

Enhancement of Anticancer Potential of Pterostilbene Derivative by Chalcone Hybridization.

Kai-Wei Tang, Chien-Chih Ke, Chih-Hua Tseng, Yeh-Long Chen, Cherng-Chyi Tzeng, Yi-Jin Chen, Chia-Chi Hsu, Hsiao-Ting Tai, Ya-Ju Hsieh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kai-Wei TangSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chien-Chih KeDepartment of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chih-Hua TsengSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0001-7392-7104
Yeh-Long ChenDrug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Cherng-Chyi TzengDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Yi-Jin ChenDepartment of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chia-Chi HsuDepartment of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Hsiao-Ting TaiDepartment of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Ya-Ju HsiehDepartment of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0003-2082-9345
Kaohsiung Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pterostilbene, a natural metabolite of resveratrol, has been indicated as a potent anticancer molecule. Recently, several pterostilbene derivatives have been reported to exhibit better anticancer activities than that of the parent pterostilbene molecule. In the present study, a series of pterostilbene derivatives were designed and synthesized by the hybridization of pterostilbene, chalcone, and cinnamic acid. The cytotoxic effect of these hybrid molecules was determined using two oral cancer cell lines, HSC-3 and OECM-1. (

Indexed as

Antineoplastic AgentsApoptosisCaspasesCell Cycle CheckpointsCell Cycle ProteinsCell DeathCell Line, TumorCell ProliferationChalconeDrug Evaluation, PreclinicalEnzyme ActivationHumansInhibitory Concentration 50Poly(ADP-ribose) PolymerasesStilbenesStructure-Activity RelationshipAntineoplastic AgentsCaspasesCell Cycle ProteinsChalconePoly(ADP-ribose) PolymerasespterostilbeneStilbenesanticancerchalcone hybridizationpterostilbene

Identifiers

PMID34443427
PMCPMC8401670
OpenAlexW3187757506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.