Evidence map›Paper›PMID 34443402›Full record

ReviewMolecules (Basel, Switzerland)2021

Fluorescent Immunoassays for Detection and Quantification of Cardiac Troponin I: A Short Review.

Remya Radha, Syeda Kiran Shahzadi, Mohammad Hussein Al-Sayah

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Cardiac troponin sensingRSC advances · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Remya RadhaDepartment of Biology, Chemistry, and Environmental Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates.
Syeda Kiran ShahzadiDepartment of Biology, Chemistry, and Environmental Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates.
Mohammad Hussein Al-SayahDepartment of Biology, Chemistry, and Environmental Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates.ORCID 0000-0001-6321-0556
American University of Sharjah · AE

Funding

American University of Sharjah BBRI18-CAS-05
6 · The paper itself

Abstract

Cardiovascular diseases are considered one of the major causes of human death globally. Myocardial infarction (MI), characterized by a diminished flow of blood to the heart, presents the highest rate of morbidity and mortality among all other cardiovascular diseases. These fatal effects have triggered the need for early diagnosis of appropriate biomarkers so that countermeasures can be taken. Cardiac troponin, the central key element of muscle regulation and contraction, is the most specific biomarker for cardiac injury and is considered the "gold standard". Due to its high specificity, the measurement of cardiac troponin levels has become the predominant indicator of MI. Various forms of diagnostic methods have been developed so far, including chemiluminescence, fluorescence immunoassay, enzyme-linked immunosorbent assay, surface plasmon resonance, electrical detection, and colorimetric protein assays. However, fluorescence-based immunoassays are considered fast, accurate and most sensitive of all in the determination of cardiac troponins post-MI. This review represents the strategies, methods and levels of detection involved in the reported fluorescence-based immunoassays for the detection of cardiac troponin I.

Indexed as

ImmunoassayBiomarkersFluorescenceHumansMyocardial InfarctionTroponin IBiomarkersTroponin Ibiosensorscardiac troponincardiovascular diseasesfluorescenceimmunoassaysmyocardial infarction

Identifiers

PMID34443402
PMCPMC8399166
OpenAlexW3187928061

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.