ReviewMolecules (Basel, Switzerland)2021
Recent Advances in the Synthesis of Ibuprofen and Naproxen.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Synthesis of 2,3-(Diheterocyclyl)Propanoic Acid Esters as New Building Blocks via Complementary Meldrum's Acid and Aza-Michael Strategies.Molecules (Basel, Switzerland) · 2026Article
- Synthesis of activated carbons and nanoparticle-loaded activated carbons derived from bio-wastes for the removal of ibuprofen drug from water.Nanoscale advances · 2026Review
- Anti-Inflammatory Effect of Resiniferatoxin During Gingival Tissue Inflammation After Mechanical Pulp Damage in a Murine Experimental Model.International journal of molecular sciences · 2026Article
- Highly Efficient Organocatalytic House-Meinwald Rearrangement for the Facile Synthesis of Aldehydes: Swift Access to Ibuprofen.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Crystallization-Induced Diastereomer Transformations of Brominated Arylacetic and Arylpyruvic Acids.The Journal of organic chemistry · 2025Article
- The effect of over-the-counter analgesics on changes to the sensory sensitivity of patients treated with transcutaneous electrical nerve stimulation.Scientific reports · 2025Observational
- Transition Metal-Free Direct Electrochemical Carboxylation of Organic Halides Using a Sacrificial Magnesium Anode: Straightforward Synthesis of Carboxylic Acids.ChemistryOpen · 2025Article
- Evaluation of physical and chemical modifications to drug reservoirs for stimuli-responsive microneedles.Drug delivery and translational research · 2025Article
- Comparison of Two Synthesis Methods for 3D PLA-Ibuprofen Nanofibrillar Scaffolds.Pharmaceutics · 2025Article
- Synthetic Strategies for the Development of Ibuprofen Derivatives: A Classified Study.Current topics in medicinal chemistry · 2025Review
- Electrical Conductivity as an Informative Factor of the Properties of Liposomal Systems with Naproxen Sodium for Transdermal Application.Materials (Basel, Switzerland) · 2024Article
- Recent highlights in the synthesis and biological significance of pyrazole derivatives.Heliyon · 2024Review
- Repurposing of halogenated organic pollutants via alkyl bromide-catalysed transfer chlorination.Nature chemistry · 2024Article
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- Novel ibuprofen prodrug: A possible promising agent for the management of complications of Alzheimer's disease.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Basil seed mucilage as a bioadhesive polymer: Development of naproxen sodium microspheres and suppositories withADMET & DMPK · 2024Article
- Role of Resolvins in Inflammatory and Neuropathic Pain.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Adsorption and Release Properties of Drug Delivery System Naproxen-SBA-15: Effect of Surface Polarity, Sodium/Acid Drug Form andJournal of functional biomaterials · 2022Article
- Novel pyrrolopyrimidine derivatives: design, synthesis, molecular docking, molecular simulations and biological evaluations as antioxidant and anti-inflammatory agents.Journal of enzyme inhibition and medicinal chemistry · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Herein, we review the recent progress in the synthesis of representative nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen and naproxen. Although these drugs were discovered over 50 years ago, novel practical and asymmetric approaches are still being developed for their synthesis. In addition, this endeavor has enabled access to more potent and selective derivatives from the key frameworks of ibuprofen and naproxen. The development of a synthetic route to ibuprofen and naproxen over the last 10 years is summarized, including developing methodologies, finding novel synthetic routes, and applying continuous-flow chemistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.