Evidence map›Paper›PMID 34443355›Full record

ArticleMolecules (Basel, Switzerland)2021

Disposition Kinetics of Amitraz in Lactating Does.

Sathish Nanjundappa, Suresh Narayanan Nair, Darsana Udayan, Sreelekha Kanapadinchareveetil, Mathew Jacob, Reghu Ravindran, Sanis Juliet

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. AMicroorganisms · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sathish NanjundappaDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Lakkidi, P.O., Wayanad 673576, Kerala, India.
Suresh Narayanan NairDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Lakkidi, P.O., Wayanad 673576, Kerala, India.ORCID 0000-0002-2178-150X
Darsana UdayanDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Lakkidi, P.O., Wayanad 673576, Kerala, India.
Sreelekha KanapadinchareveetilDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Lakkidi, P.O., Wayanad 673576, Kerala, India.
Mathew JacobDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Lakkidi, P.O., Wayanad 673576, Kerala, India.
Reghu RavindranDepartment of Veterinary Parasitology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Lakkidi, P.O., Wayanad 673576, Kerala, India.ORCID 0000-0001-9250-0552
Sanis JulietDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Lakkidi, P.O., Wayanad 673576, Kerala, India.
Kerala Veterinary and Animal Sciences University · IN

Funding

Indian Council of Agricultural Research NAIP/C2066, NFBSFARA/BSA-4004/2013-14, NASF/ABA-6015/2016-17, No. 7(2)/-2011-EPDNational Bank for Agriculture and Rural Development G.O.(Rt)No.100/12/ AD RIDF XVI KERALA
6 · The paper itself

Abstract

Amitraz, a member of the formamidine pesticide family, commonly used for ectoparasite control, is applied as a dip or low-pressure hand spray to cattle and swine, and the neck collar on dogs. Data on amitraz were generated mainly on laboratory animals, hens, dogs, and baboons. The data on the toxicity and disposition of amitraz in animals and its residues in the milk are inadequate. Therefore, the present study was intended to analyze the disposition kinetics of amitraz and its pattern of elimination in the milk of lactating does after a single dermal application at a concentration of 0.25%. Blood at predetermined time intervals and milk twice daily were collected for eight days post application. The drug concentration was assayed by high-performance liquid chromatography (HPLC). Amitraz was detected in whole blood as early as 0.5 h, which attained a peak concentration at 12 ± 5 h, followed by a steady decline; however, detection persisted until 168 h. Amitraz was present in the blood at its 50% C

Indexed as

LactationToluidinesAnimalsCattleFemaleHalf-LifeKineticsMilkamitrazToluidinesblood concentrationdermalformamidine ectoparasiticideHPLCmilk

Identifiers

PMID34443355
PMCPMC8400832
OpenAlexW3193202405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.