ReviewMolecules (Basel, Switzerland)2021
New Insights on the Interaction of Phenanthroline Based Ligands and Metal Complexes and Polyoxometalates with Duplex DNA and G-Quadruplexes.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Synthesis and Characterization of 1,10-Phenanthroline-Linked Imidazolium Salts: Investigation of Their Cytotoxicity Properties.ACS omega · 2026Article
- DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline.International journal of molecular sciences · 2024Article
- Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano-Bio-Platforms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- G-Quadruplexes Formation by theMolecules (Basel, Switzerland) · 2023Article
- Exploring the Reactivity of Polyoxometalates toward Proteins: From Interactions to Mechanistic Insights.JACS Au · 2023Review
- Influence of conventional hydrogen bonds in the intercalation of phenanthroline derivatives with DNA: The important role of the sugar and phosphate backbone.Journal of computational chemistry · 2022Article
- Sublimation Study of Six 5-Substituted-1,10-Phenanthrolines by Knudsen Effusion Mass Loss and Solution Calorimetry.Entropy (Basel, Switzerland) · 2022Article
- Editorial: Emerging polyoxometalates with biological, biomedical, and health applications.Frontiers in chemistry · 2022Article
- Computational Modelling of the Interactions Between Polyoxometalates and Biological Systems.Frontiers in chemistry · 2022Review
- Benchmark Force Fields for the Molecular Dynamic Simulation of G-Quadruplexes.Molecules (Basel, Switzerland) · 2021Article
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
This work provides new insights from our team regarding advances in targeting canonical and non-canonical nucleic acid structures. This modality of medical treatment is used as a form of molecular medicine specifically against the growth of cancer cells. Nevertheless, because of increasing concerns about bacterial antibiotic resistance, this medical strategy is also being explored in this field. Up to three strategies for the use of DNA as target have been studied in our research lines during the last few years: (1) the intercalation of phenanthroline derivatives with duplex DNA; (2) the interaction of metal complexes containing phenanthroline with G-quadruplexes; and (3) the activity of Mo polyoxometalates and other Mo-oxo species as artificial phosphoesterases to catalyze the hydrolysis of phosphoester bonds in DNA. We demonstrate some promising computational results concerning the favorable interaction of these small molecules with DNA that could correspond to cytotoxic effects against tumoral cells and microorganisms. Therefore, our results open the door for the pharmaceutical and medical applications of the compounds we propose.
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Registered trials
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