Evidence map›Paper›PMID 34443308›Full record

ArticleMolecules (Basel, Switzerland)2021

Design, Synthesis and Anticancer Evaluation of Substituted Cinnamic Acid Bearing 2-Quinolone Hybrid Derivatives.

Ali H Abu Almaaty, Nermeen A Elgrahy, Eman Fayad, Ola A Abu Ali, Ahmed R E Mahdy, Lamiaa A A Barakat, Mohammed El Behery

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Therapeutic Potental of Quinolin-2Mini reviews in medicinal chemistry · 2025
    Review
  3. Review
  4. Future medicinal chemistry · 2024
    Article
  5. Review
  6. Synthesis and Anticancer Evaluation of Novel 7-Aza-Coumarine-3-Carboxamides.International journal of molecular sciences · 2023
    Article
  7. Article
  8. Article
  9. Design and Synthesis of New Pyrimidine-Quinolone Hybrids as NovelPharmaceuticals (Basel, Switzerland) · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ali H Abu AlmaatyZoology Department, Faculty of Science, Port Said University, Port Said 42526, Egypt.ORCID 0000-0001-9056-0228
Nermeen A ElgrahyChemistry Department (The Division of Biochemistry), Faculty of Science, Port Said University, Port Said 42526, Egypt.
Eman FayadDepartment of Biotechnology, Faculty of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0003-2916-0254
Ola A Abu AliDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Ahmed R E MahdyChemistry Department (The Division of Organic Chemistry), Faculty of Science, Port Said University, Port Said 42526, Egypt.
Lamiaa A A BarakatChemistry Department (The Division of Biochemistry), Faculty of Science, Port Said University, Port Said 42526, Egypt.
Mohammed El BeheryChemistry Department (The Division of Biochemistry), Faculty of Science, Port Said University, Port Said 42526, Egypt.

Funding

Taif University This work was supported by Taif University Researchers Supporting project number (TURSP-2020/220), Taif University, Taif, Saudi Arabia.
6 · The paper itself

Abstract

A new series of hybrid molecules containing cinnamic acid and 2-quinolinone derivatives were designed and synthesized. Their structures were confirmed by

Indexed as

Drug DesignAntineoplastic AgentsApoptosisCell CycleCell DeathCell Line, TumorCinnamatesDNA Topoisomerases, Type IIHumansInhibitory Concentration 50Molecular Docking SimulationQuinolonesTopoisomerase InhibitorsAntineoplastic AgentsCinnamatescinnamic acidDNA Topoisomerases, Type IIQuinolonesTopoisomerase Inhibitors2-quinolone hybrid derivativesapoptosiscell cycle analysiscytotoxicitytopoisomerase II

Identifiers

PMID34443308
PMCPMC8400797

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.