Evidence map›Paper›PMID 34443296›Full record

ArticleMolecules (Basel, Switzerland)2021

Design of Liposomes Carrying HelixComplex Snail Mucus: Preliminary Studies.

Andrea Alogna, Valentina Gentili, Claudio Trapella, Supandeep Singh Hallan, Maddalena Sguizzato, Giovanni Strazzabosco, Mercedes Fernández, Rita Cortesi, Roberta Rizzo, Daria Bortolotti

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. LiposomalInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Chemical Variability and Biological Potential ofMolecules (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Andrea AlognaDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.ORCID 0000-0002-1786-6324
Valentina GentiliDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.ORCID 0000-0003-4572-5497
Claudio TrapellaDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.
Supandeep Singh HallanDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.ORCID 0000-0002-2882-0719
Maddalena SguizzatoDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.ORCID 0000-0002-2100-2043
Giovanni StrazzaboscoDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.
Mercedes FernándezDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.ORCID 0000-0003-1237-5275
Rita CortesiDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.ORCID 0000-0002-1060-2676
Roberta RizzoDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.ORCID 0000-0001-9507-9126
Daria BortolottiDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.ORCID 0000-0003-4496-9561
University of Ferrara · IT

Funding

Chamber of Commerce of Ferrara CCIAA2018Chamber of Commerce of Ferrara CCIAA2019PON "Research and Innovation" 2014-2020 ARS01_01163University of Ferrara FAR2019University of Ferrara FAR2020
6 · The paper itself

Abstract

In recent decades liposomes have been used in different field thanks to their ability to act as a vehicle for a wide range of biomolecules, their great versatility and their easy production. The aim of this study was to evaluate liposomes as a vehicle for the actives present in the HelixComplex (HC) snail mucus for topical delivery. Liposomes composed of a mixture of phosphatidylcholine, cholesterol and octadecylamine were prepared with and without HC (empty liposomes) and their biological efficacy was tested by evaluating cell viability and migration. HC-loaded liposomes (LHC) were stable throughout 60 days of observation, and showed interesting effects on wound healing reconstitution. In particular, we observed that 25 µg/mL LHC were already able to induce a higher cell monolayer reconstitution in comparison to the untreated samples and HC treated samples after only 4 h (28% versus 10% and 7%,

Indexed as

AnimalsCell DeathCell LineFibroblastsFreeze FracturingHumansLipidsLiposomesMucusSnailsSpectrophotometry, InfraredWound HealingLipidsLiposomesdrug deliveryHelixComplexliposomesMTT testslime mucus

Identifiers

PMID34443296
PMCPMC8399803
OpenAlexW3189682058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.