ArticleMaterials (Basel, Switzerland)2021
Sustainable Surface Modification of Polyetheretherketone (PEEK) Implants by Hydroxyapatite/Silica Coating-An In Vivo Animal Study.
Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Network Toxicology and Molecular Docking Analysis of Targets and Potential Mechanisms of PEEK-Induced Bone Resorption.International journal of molecular sciences · 2026Article
- Outcomes comparison between novel hydroxyapatite enhanced polyetheretherketone and titanium implants after anterior lumbar interbody fusion.Journal of spine surgery (Hong Kong) · 2026Article
- Polyetheretherketone (PEEK) in maxillofacial reconstruction surgery: a narrative review.Annals of medicine and surgery (2012) · 2026Review
- Role of polyetheretherketone (PEEK) in arthroplasty and orthopaedics: a review of biomechanical properties, surface modifications, and clinical outcomes.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Review
- Impact of laser modification on the contact angle and surface wettability of hydroxyapatite-coated PEEK implant material.Frontiers in dental medicine · 2026Article
- Nanostructured implants for enhanced integration and localized therapy.BioImpacts : BI · 2026Review
- Gradient 3D printed PEEK with nano-coating facilitates rapid manufacturing with dual enhanced osteogenic and anti-bacterial property.Materials today. Bio · 2025Article
- Impact of PEEK implant surface design on postoperative complications in cranioplasty: a retrospective review.Chinese neurosurgical journal · 2025Article
- CF-PEEK vs. Titanium Dental Implants: Stress Distribution and Fatigue Performance in Variable Bone Qualities.Biomimetics (Basel, Switzerland) · 2025Article
- Biomaterials and Tissue Engineering in Neurosurgery: Current Innovations and Future Directions.Biotech (Basel (Switzerland)) · 2025Review
- Nano-Based Approaches in Surface Modifications of Dental Implants: A Literature Review.Molecules (Basel, Switzerland) · 2024Review
- Safety and Efficacy of Zero-Profile Polyetheretherketone (PEEK) Cages Filled with Biphasic Calcium Phosphate (BCP) in Anterior Cervical Discectomy and Fusion (ACDF): A Case Series.Journal of clinical medicine · 2024Article
- Surface modification of PEEK implants for craniofacial reconstruction and aesthetic augmentation-fiction or reality?Frontiers in surgery · 2024Review
- Latest advances: Improving the anti-inflammatory and immunomodulatory properties of PEEK materials.Materials today. Bio · 2023Review
- Precision of polyether ether ketone (PEEK) or cobalt-chrome implant bar fit to implants after mechanical cycling.Acta odontologica latinoamericana : AOL · 2023Article
- Implant Materials for Anterior Column Reconstruction of Cervical Spine Tumor.Orthopaedic surgery · 2023Review
- Customized Barrier Membrane (Titanium Alloy, Poly Ether-Ether Ketone and Unsintered Hydroxyapatite/Poly-l-Lactide) for Guided Bone Regeneration.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Polyetheretherketone (PEEK) has the potential to overcome some of the disadvantages of titanium interbody implants in anterior cervical and discectomy and fusion (ACDF). However, PEEK shows an inferior biological behavior regarding osseointegration and bioactivity. Therefore, the aim of the study was to create a bioactive surface coating on PEEK implants with a unique nanopore structure enabling the generation of a long-lasting interfacial composite layer between coating material and implant. Seventy-two PEEK implants-each thirty-six pure PEEK implants (PI) and thirty-six PEEK implants with a sprayed coating consisting of nanocrystalline hydroxyapatite (ncHA) embedded in a silica matrix and interfacial composite layer (SPI)-were inserted in the femoral condyles of adult rats using a split-side model. After 2, 4 and 8 weeks, the femur bones were harvested. Half of the femur bones were used in histological and histomorphometrical analyses. Additionally, pull-out tests were performed in the second half. Postoperative healing was uneventful for all animals, and no postoperative complications were observed. Considerable crestal and medullary bone remodeling could be found around all implants, with faster bone formation around the SPI and fewer regions with fibrous tissue barriers between implant and bone. Histomorphometrical analyses showed a higher bone to implant contact (BIC) in SPI after 4 and 8 weeks (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.