Evidence map›Paper›PMID 34442829›Full record

ArticleMicroorganisms2021

Nicastrin-Like, a Novel Transmembrane Protein from

Guilherme Curty Lechuga, Paloma Napoleão-Pêgo, Larissa Rodrigues Gomes, Andressa da Matta Durans, David William Provance, Salvatore Giovanni De-Simone

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Membranes · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Guilherme Curty LechugaFIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Populations (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.ORCID 0000-0003-4538-3802
Paloma Napoleão-PêgoFIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Populations (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.
Larissa Rodrigues GomesFIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Populations (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.
Andressa da Matta DuransFIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Populations (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.
David William ProvanceFIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Populations (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-9824-0672
Salvatore Giovanni De-SimoneFIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Populations (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-2172-656X
Fundação Oswaldo Cruz · BRUniversidade Federal Fluminense · BR

Funding

Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro FAPERJ #110.198-13; #E26 202.841-2018Conselho Nacional de Desenvolvimento Científico e Tecnológico #467.488.2014-2; #3075732011; #3013322015-0; #3806232019-6Coordenação de Aperfeiçoamento de Pessoal de Nível Superior #001-2010
6 · The paper itself

Abstract

Nicastrin (NICT) is a transmembrane protein physically associated with the polytypical aspartyl protease presenilin that plays a vital role in the correct localization and stabilization of presenilin to the membrane-bound γ-secretase complex. This complex is involved in the regulation of a wide range of cellular events, including cell signaling and the regulation of endocytosed membrane proteins for their trafficking and protein processing. Methods: In

Indexed as

B-cell epitopeflagellar pocketnicastrinpresenilinSPOT synthesistransmembrane motifTrypanosoma cruzitype I transmembrane glycoproteinvesicular traffickingγ-secretase

Identifiers

PMID34442829
PMCPMC8400621
OpenAlexW3173403552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.