Evidence map›Paper›PMID 34442806›Full record

ArticleMicroorganisms2021

Impact of Age and Sex on Antibody Response Following the Second Dose of COVID-19 BNT162b2 mRNA Vaccine in Greek Healthcare Workers.

Niki Vassilaki, Antonios N Gargalionis, Anastasia Bletsa, Nikolaos Papamichalopoulos, Elisavet Kontou, Meropi Gkika, Kostas Patas, Dimitrios Theodoridis, Ioannis Manolis, Anastasios Ioannidis and 4 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 58 citations in OpenAlex.

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  19. Coronavirus Vaccination: Spike Antibody Levels in Health Workers after Six Months-A Cross-Sectional Study.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Niki VassilakiLaboratory of Molecular Virology, Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue, 11521 Athens, Greece.
Antonios N GargalionisDepartment of Medical Biopathology, Eginition Hospital, Athens Medical School, National and Kapodistrian University of Athens, 72-74 Vasilissis Sofias Avenue, 11528 Athens, Greece.
Anastasia BletsaImmunology-Histocompatibility Department of Evangelismos General Hospital, Ypsilantou Str. 45-47, 10676 Athens, Greece.
Nikolaos PapamichalopoulosDepartment of Medical Biopathology, Eginition Hospital, Athens Medical School, National and Kapodistrian University of Athens, 72-74 Vasilissis Sofias Avenue, 11528 Athens, Greece.
Elisavet KontouImmunology-Histocompatibility Department of Evangelismos General Hospital, Ypsilantou Str. 45-47, 10676 Athens, Greece.
Meropi GkikaDepartment of Medical Biopathology, Eginition Hospital, Athens Medical School, National and Kapodistrian University of Athens, 72-74 Vasilissis Sofias Avenue, 11528 Athens, Greece.
Kostas PatasDepartment of Medical Biopathology, Eginition Hospital, Athens Medical School, National and Kapodistrian University of Athens, 72-74 Vasilissis Sofias Avenue, 11528 Athens, Greece.
Dimitrios TheodoridisDepartment of Medical Biochemistry, Konstantopoulio-Patision General Hospital, Agias Olgas 3-5, 14233 Nea Ionia, Greece.
Ioannis ManolisDepartment of Medical Biochemistry, Konstantopoulio-Patision General Hospital, Agias Olgas 3-5, 14233 Nea Ionia, Greece.
Anastasios IoannidisDepartment of Nursing, Faculty of Health Sciences, University of Peloponnese, Sehi Area, 22100 Tripoli, Greece.ORCID 0000-0003-1880-7366
Raphaela S MilonaLaboratory of Molecular Virology, Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue, 11521 Athens, Greece.
Alexandra TsirogianniImmunology-Histocompatibility Department of Evangelismos General Hospital, Ypsilantou Str. 45-47, 10676 Athens, Greece.
Emmanouil AngelakisDepartment of Diagnostics, Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue, 11521 Athens, Greece.
Stylianos ChatzipanagiotouDepartment of Medical Biopathology, Eginition Hospital, Athens Medical School, National and Kapodistrian University of Athens, 72-74 Vasilissis Sofias Avenue, 11528 Athens, Greece.ORCID 0000-0002-1251-8355
National and Kapodistrian University of Athens · GREvangelismos Hospital · GRAgia Olga Hospital · GRPasteur Hellenic Institute · GRAix-Marseille Université · FRUniversity of Peloponnese · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-SARS-CoV-2 spike RBD (receptor-binding domain) IgG antibody levels were monitored in 1643 volunteer healthcare workers of Eginition, Evangelismos, and Konstantopoulio General Hospitals (Athens, Greece), who underwent vaccination with two doses of COVID-19 BNT162b2 mRNA vaccine (Pfizer) and had no history of SARS-CoV-2 infection. Venous blood was collected 20-30 days after the second vaccine dose and anti-RBD IgG levels were determined using CMIA SARS-CoV-2 IgG II Quant (Abbott) on ARCHITECT i System or ADVIA Centaur SARS-CoV-2 IgG (Siemens) on Centaur XP platform. From the total population of 1643 vaccinees (533 M/1110 F; median age = 49; interquartile range-IQR = 40-56), 1636 (99.6%) had anti-SARS-CoV-2 IgG titers above the positivity threshold of the assay used. One-Way ANOVA Kruskal-Wallis H test showed a statistically significant difference in the median of antibody titers between the different age groups (

Indexed as

BNT162b2 mRNACOVID-19healthcare workersSARS-CoV-2 IgG

Identifiers

PMID34442806
PMCPMC8401044
OpenAlexW3194347237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.