Evidence map›Paper›PMID 34442725›Full record

ArticleMicroorganisms2021

Evolutionary Diversification of Host-Targeted

Tilman Schirmer, Tjaart A P de Beer, Stefanie Tamegger, Alexander Harms, Nikolaus Dietz, David M Dranow, Thomas E Edwards, Peter J Myler, Isabelle Phan, Christoph Dehio

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Translocation of YopJ family effector proteins through the VirB/VirD4 T4SS ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. The Impact ofFrontiers in microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Tilman SchirmerBiozentrum, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0001-9512-8346
Tjaart A P de BeerBiozentrum, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0001-5966-6091
Stefanie TameggerBiozentrum, University of Basel, 4056 Basel, Switzerland.
Alexander HarmsBiozentrum, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0003-2106-1286
Nikolaus DietzBiozentrum, University of Basel, 4056 Basel, Switzerland.
David M DranowSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109, USA.
Thomas E EdwardsSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109, USA.
Peter J MylerSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109, USA.
Isabelle PhanSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109, USA.ORCID 0000-0001-6873-3401
Christoph DehioBiozentrum, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0001-7288-1052
University of Basel · CHBeryllium (United States) · USSeattle Children's Hospital · USUniversity of Washington · US

Funding

European Research Council 340330National Institute of Allergy and Infectious Diseases HHNSN272201200025CNational Institute of Allergy and Infectious Diseases HHNSN272201700059CSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030B_201273Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A_173119
6 · The paper itself

Abstract

Proteins containing a FIC domain catalyze AMPylation and other post-translational modifications (PTMs). In bacteria, they are typically part of FicTA toxin-antitoxin modules that control conserved biochemical processes such as topoisomerase activity, but they have also repeatedly diversified into host-targeted virulence factors. Among these,

Indexed as

adenylylationAMPylationbacterial effector proteinBartonella effector proteinBepBID domainde-AMPylationFIC domainFIC signature loopFicT/FicA toxin-antitoxin moduleOB-foldtype IV secretion systemVirB/VirD4

Identifiers

PMID34442725
PMCPMC8401265
OpenAlexW3192397504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.