Evidence map›Paper›PMID 34442689›Full record

ArticleMicroorganisms2021

Cyclofaulknamycin with the Rare Amino Acid D-capreomycidine Isolated from a Well-Characterized

Liliya Horbal, Marc Stierhof, Anja Palusczak, Nikolas Eckert, Josef Zapp, Andriy Luzhetskyy

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Enzymatic CJournal of the American Chemical Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Liliya HorbalDepartment of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany.
Marc StierhofDepartment of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany.
Anja PalusczakDepartment of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany.
Nikolas EckertAMEG Department, Helmholtz Institute for Pharmaceutical Research Saarland, 66123 Saarbruecken, Germany.
Josef ZappDepartment of Pharmaceutical Biology, Saarland University, 66123 Saarbruecken, Germany.
Andriy LuzhetskyyDepartment of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany.
Saarland University · DEHelmholtz Institute for Pharmaceutical Research Saarland · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeted genome mining is an efficient method of biosynthetic gene cluster prioritization within constantly growing genome databases. Using two capreomycidine biosynthesis genes, alpha-ketoglutarate-dependent arginine beta-hydroxylase and pyridoxal-phosphate-dependent aminotransferase, we identified two types of clusters: one type containing both genes involved in the biosynthesis of the abovementioned moiety, and other clusters including only arginine hydroxylase. Detailed analysis of one of the clusters, the

Indexed as

cyclofaulknamycincyclopeptideD-capreomycidineStreptomyces

Identifiers

PMID34442689
PMCPMC8399532
OpenAlexW3183511596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.