Evidence map›Paper›PMID 34442687›Full record

ArticleMicroorganisms2021

Family SES Is Associated with the Gut Microbiome in Infants and Children.

Candace R Lewis, Kevin S Bonham, Shelley Hoeft McCann, Alexandra R Volpe, Viren D'Sa, Marcus Naymik, Matt D De Both, Matthew J Huentelman, Kathryn Lemery-Chalfant, Sarah K Highlander and 2 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Candace R LewisNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.ORCID 0000-0001-5253-9989
Kevin S BonhamDepartment of Biological Sciences, Wellesley College, Wellesley, MA 02481, USA.
Shelley Hoeft McCannDepartment of Biological Sciences, Wellesley College, Wellesley, MA 02481, USA.
Alexandra R VolpeAdvanced Baby Imaging Lab, Hasbro Children's Hospital, Rhode Island Hospital, Providence, RI 02903, USA.
Viren D'SaAdvanced Baby Imaging Lab, Hasbro Children's Hospital, Rhode Island Hospital, Providence, RI 02903, USA.
Marcus NaymikNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Matt D De BothNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Matthew J HuentelmanNeurogenomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.ORCID 0000-0001-7390-9918
Kathryn Lemery-ChalfantPsychology Department, Arizona State University, Tempe, AZ 85281, USA.
Sarah K HighlanderPathogen and Microbiome Division, Translational Genomics Research Institute North (TGen), Flagstaff, AZ 86005, USA.
Sean C L DeoniAdvanced Baby Imaging Lab, Hasbro Children's Hospital, Rhode Island Hospital, Providence, RI 02903, USA.
Vanja Klepac-CerajDepartment of Biological Sciences, Wellesley College, Wellesley, MA 02481, USA.ORCID 0000-0001-5387-5706
Translational Genomics Research Institute · USWellesley College · USArizona State University · USBrown University · USGates Foundation · USRhode Island Hospital · US

Funding

The Developing Brain: Influences and OutcomesUG3OD023313 · OD · UNIVERSITY OF COLORADO DENVER · PI D'SA, VIREN ANDREW, KOINIS MITCHELL, DAPHNE · 2016 to 2024
$11.6M
Genetic and Environmental Origins of the Development of Pain in ChildrenR01HD086085 · NICHD · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Mary Colleen Davis, Kathryn Lemery-Chalfant · 2016 to 2026
$6.0M
Social and Genetic Contributions to Children's Sleep, Health, and FunctioningR01HD079520 · NICHD · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI DOANE SAMPEY, LEAH DARRAH, LEMERY-CHALFANT, KATHRYN · 2015 to 2025
$6.0M
Host DNA methylation as a mechanism of microbiome influence on internalizing behaviorR00HD099307 · NICHD · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LEWIS, CANDACE RENEE · 2022 to 2024
$703k
Host DNA methylation as a mechanism of microbiome influence on internalizing behaviorK99HD099307 · NICHD · TRANSLATIONAL GENOMICS RESEARCH INST · PI LEWIS, CANDACE RENEE · 2020 to 2021
$194k
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1K99HD099307-01A1NICHD NIH HHS K99 HD099307NICHD NIH HHS R00 HD099307NICHD NIH HHS R01 HD079520NICHD NIH HHS R01 HD086085NIH HHS R34-DA050284NIH Office of the Director UG3OD023313
6 · The paper itself

Abstract

backgroundWhile early life exposures such as mode of birth, breastfeeding, and antibiotic use are established regulators of microbiome composition in early childhood, recent research suggests that the social environment may also exert influence. Two recent studies in adults demonstrated associations between socioeconomic factors and microbiome composition. This study expands on this prior work by examining the association between family socioeconomic status (SES) and host genetics with microbiome composition in infants and children.

methodsFamily SES was used to predict a latent variable representing six genera abundances generated from whole-genome shotgun sequencing. A polygenic score derived from a microbiome genome-wide association study was included to control for potential genetic associations. Associations between family SES and microbiome diversity were assessed.

results

conclusionsOur results demonstrate that modifiable environmental factors influence gut microbiome composition at an early age. These results are important as our understanding of gut microbiome influences on health continue to expand.

Indexed as

childhoodinfantmicrobiomesocioeconomic statusstress

Identifiers

PMID34442687
PMCPMC8398307
OpenAlexW3186394908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.