Evidence map›Paper›PMID 34442539›Full record

ArticleMicromachines2021

Metal-Free Fabrication of Fused Silica Extended Nanofluidic Channel to Remove Artifacts in Chemical Analysis.

Kyojiro Morikawa, Ryoichi Ohta, Kazuma Mawatari, Takehiko Kitamori

Open access · goldAbstract read
In one paragraph

Article in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Accelerated protein digestion by numbering-up nanochannels, followed by LC-MS analysis.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026
    Article
  2. Article
  3. Article
  4. High-temperature ultrafast ChipHPLC-MS.Analytical and bioanalytical chemistry · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kyojiro MorikawaCollaborative Research Organization for Micro and Nano Multifunctional Devices (NMfD), The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan.ORCID 0000-0002-9163-9373
Ryoichi OhtaCollaborative Research Organization for Micro and Nano Multifunctional Devices (NMfD), The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan.
Kazuma MawatariDepartment of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan.
Takehiko KitamoriCollaborative Research Organization for Micro and Nano Multifunctional Devices (NMfD), The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan.
The University of Tokyo · JPNational Tsing Hua University · TW

Funding

Japan Science and Technology Agency JPMJCR14G1Japan Society for the Promotion of Science JP19K15417
6 · The paper itself

Abstract

In microfluidics, especially in nanofluidics, nanochannels with functionalized surfaces have recently attracted attention for use as a new tool for the investigation of chemical reaction fields. Molecules handled in the reaction field can reach the single-molecule level due to the small size of the nanochannel. In such surroundings, contamination of the channel surface should be removed at the single-molecule level. In this study, it was assumed that metal materials could contaminate the nanochannels during the fabrication processes; therefore, we aimed to develop metal-free fabrication processes. Fused silica channels 1000 nm-deep were conventionally fabricated using a chromium mask. Instead of chromium, electron beam resists more than 1000 nm thick were used and the lithography conditions were optimized. From the results of optimization, channels with 1000 nm scale width and depth were fabricated on fused silica substrates without the use of a chromium mask. In nanofluidic experiments, an oxidation reaction was observed in a device fabricated by conventional fabrication processes using a chromium mask. It was found that Cr

Indexed as

extended nanochannelfused silicametal-freemicrofluidicsnanofabricationnanofluidics

Identifiers

PMID34442539
PMCPMC8399996
OpenAlexW3187834931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.