Evidence map›Paper›PMID 34442438›Full record

ArticleJournal of personalized medicine2021

ILB

Giacomo Lazzarino, Renata Mangione, Antonio Belli, Valentina Di Pietro, Zsuzsanna Nagy, Nicholas M Barnes, Lars Bruce, Bernardo M Ropero, Lennart I Persson, Benedetta Manca and 5 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03613571 (A Single-centre, Open Single-arm Study Where the Safety, Tolerability and Efficacy of Subcutaneously Administered ILB Will be Evaluated in Patients With Amyotrophic Lateral Sclerosis), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03613571 phase2terminatednot on this map

A Single-centre, Open Single-arm Study Where the Safety, Tolerability and Efficacy of Subcutaneously Administered ILB Will be Evaluated in Patients With Amyotrophic Lateral Sclerosis

TypeinterventionalSponsorTikoMed ABRan2018 to 2019Enrolled13ConditionsAmyotrophic Lateral SclerosisArmsILB
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. ILBInternational journal of molecular sciences · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Giacomo LazzarinoUniCamillus, Saint Camillus International University of Health Sciences, 00131 Rome, Italy.ORCID 0000-0003-1639-0966
Renata MangioneDepartment of Basic Biotechnological Sciences, Intensive and Perioperative Clinics, Catholic University of Rome, 00168 Rome, Italy.
Antonio BelliCollege of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Valentina Di PietroCollege of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Zsuzsanna NagyCollege of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Nicholas M BarnesCollege of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Lars BruceTikomed AB, 263 03 Viken, Sweden.
Bernardo M RoperoDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, 413 90 Gothenburg, Sweden.
Lennart I PerssonDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, 413 90 Gothenburg, Sweden.
Benedetta MancaDepartment of Pharmacy and Biotechnology (FaBiT), University of Bologna, 40126 Bologna, Italy.
Miriam Wissam SaabDepartment of Biomedical and Biotechnological Sciences, Division of Medical Biochemistry, University of Catania, 95123 Catania, Italy.
Angela M AmoriniDepartment of Biomedical and Biotechnological Sciences, Division of Medical Biochemistry, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-3525-9955
Barbara TavazziUniCamillus, Saint Camillus International University of Health Sciences, 00131 Rome, Italy.ORCID 0000-0001-8743-0895
Giuseppe LazzarinoDepartment of Biomedical and Biotechnological Sciences, Division of Medical Biochemistry, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-5917-7279
Ann LoganBiomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
University of Catania · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Birmingham · GBTikomed (Sweden) · SEUniversity of Gothenburg · SEUniversity of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative/nitrosative stress and mitochondrial dysfunction is a hallmark of amyotrophic lateral sclerosis (ALS), an invariably fatal progressive neurodegenerative disease. Here, as an exploratory arm of a phase II clinical trial (EudraCT Number 2017-005065-47), we used high performance liquid chromatography(HPLC) to investigate changes in the metabolic profiles of serum from ALS patients treated weekly for 4 weeks with a repeated sub-cutaneous dose of 1 mg/kg of a proprietary low molecular weight dextran sulphate, called ILB

Indexed as

amino acidsamyotrophic lateral sclerosisantioxidantsenergy metabolismHPLClow molecular weight-dextran sulphatemitochondrial dysfunctionN-acetylaspartateoxidative/nitrosative stressserum biomarkers

Identifiers

PMID34442438
PMCPMC8399678
OpenAlexW3188727573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.