Evidence map›Paper›PMID 34442434›Full record

ArticleJournal of personalized medicine2021

Personalizing Medicine and Technologies to Address the Experiences and Needs of People with Multiple Sclerosis.

Adam Henschke, Jane Desborough, Anne Parkinson, Crystal Brunoro, Vanessa Fanning, Christian Lueck, Nicola Brew-Sam, Anne Brüstle, Janet Drew, Katrina Chisholm and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Review
  5. Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Adam HenschkeDepartment of Philosophy, Faculty of Behavioural, Management, and Social Sciences, University of Twente, 7522 Enschede, The Netherlands.ORCID 0000-0002-2956-0883
Jane DesboroughDepartment of Health Services Research and Policy, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra 2601, Australia.
Anne ParkinsonDepartment of Health Services Research and Policy, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra 2601, Australia.ORCID 0000-0001-9053-0707
Crystal BrunoroDepartment of Health Services Research and Policy, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra 2601, Australia.
Vanessa FanningDepartment of Health Services Research and Policy, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra 2601, Australia.
Christian LueckAustralian National University Medical School, College of Health and Medicine, Australian National University, Canberra 2601, Australia.
Nicola Brew-SamDepartment of Health Services Research and Policy, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra 2601, Australia.
Anne BrüstleJohn Curtin School of Medical Research, College of Health and Medicine, Australian National University, Canberra 2601, Australia.ORCID 0000-0002-3842-5683
Janet DrewDepartment of Health Services Research and Policy, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra 2601, Australia.
Katrina ChisholmDepartment of Health Services Research and Policy, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra 2601, Australia.
Mark ElishaDepartment of Health Services Research and Policy, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra 2601, Australia.
Hanna SuominenSchool of Computing, College of Engineering and Computer Science, Australian National University, Canberra 2601, Australia.
Antonio TricoliResearch School of Chemistry, College of Science, Australian National University, Canberra 2601, Australia.
Christine PhillipsAustralian National University Medical School, College of Health and Medicine, Australian National University, Canberra 2601, Australia.
Matthew CookJohn Curtin School of Medical Research, College of Health and Medicine, Australian National University, Canberra 2601, Australia.

Funding

Australian National University Grand Challenge
6 · The paper itself

Abstract

There is enormous variation in the manifestations of disease experienced by people with multiple sclerosis (PwMS). While this variation makes personalized medicine an attractive goal, there are many challenges to be overcome before this opportunity can be realized. Personalized medicine often focuses on targeted therapies and detailed monitoring, but we also need to recognize that there will be variation in acceptance of these approaches by different PwMS. In other words, deep personalization of medicine will encompass targeted therapy, precision monitoring, tailored to variation in personal attitudes to these transformations in health care. In order to meet the promise of personalized medicine for MS, understanding the experiences of PwMS is necessary both to aid in the uptake of personalized medicine, and to ensure that personalized approaches to monitoring disease and treatment provide a net benefit to PwMS rather than placing additional burdens and stressors on them. Here, we describe recent research that identified five experiential themes for PwMS, and then interpret these themes according to the foundations of personalized medicine to provide a road map for implementation of personalized medicine solutions for PwMS.

Indexed as

fatigue managementlived experiencemultiple sclerosispersonalized medicineuncertainty

Identifiers

PMID34442434
PMCPMC8401762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.