ArticleJournal of personalized medicine2021
Improvement of Cognitive Function and Interleukin 1 Beta Serum Concentrations Following Cardiac Pacemaker Implantation in Patients with Symptomatic Bradycardia.
Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 6 citations in OpenAlex.
- At the Intersection of Psychiatry and Cardiology: Assessment of Depressive, Anxiety and Cognitive Disorders in Patients Before and After the Implantation of Cardiac Implantable Electronic Devices.Medicina (Kaunas, Lithuania) · 2026Review
- Sinus Pause and Cognitive Dysfunction: Diagnostic and Therapeutic Implications.Clinical case reports · 2026Article
- Association of Atrial Electrophysiological Abnormalities With Cognitive Decline and Cerebrovascular Disease.Journal of the American Heart Association · 2026Article
- U-shaped association of resting heart rate with cognitive decline.Brain communications · 2025Article
- Research progress on the interaction between multiple organ-brain axes and perioperative neurocognitive disorders: a narrative review.Frontiers in aging neuroscience · 2025Review
- Pacemaker Implants and Their Influence on the Daily Life of Patients with Dementia with Lewy Bodies: A Qualitative Case Study.Neurology and therapy · 2023Article
- Pathophysiology of cognitive dysfunction and the role of combined brain/heart magnetic resonance imaging (Review).Experimental and therapeutic medicine · 2022Review
- Computational Analysis of a Multi-Layered Skin and Cardiac Pacemaker Model Based on Neural Network Approach.Sensors (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimBradyarrhythmias cause a low cerebral blood flow with secondary neuronal ischemia and cognitive dysfunction. This study aims to assess the effect of cardiac pacemaker implantation (PI) on the cognitive function and inflammatory markers (TNF alpha, IL1β). MATERIAL AND
methodWe conducted a prospective observational study on a number of 31 patients with symptomatic bradyarrhythmias. We performed the cognitive function assessment by two tests (Mini-Mental State Examination and Trail Making Test A), cardiac output assessment (echocardiographic), and determination of IL 1β and TNF alpha serum concentrations before pacemaker implantation and after an average period of 42 days from pacemaker implantation.
resultsAfter pacemaker implantation we observed an increase in the cardiac index by 0.71 L/min/m
conclusionsOur findings suggest that cardiac pacemaker implantation was associated with improved cognitive function-possibly related to an increased cardiac output and with adecreased serum IL1β concentration in subjects with symptomatic bradycardia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.