Evidence map›Paper›PMID 34442380›Full record

ArticleJournal of personalized medicine2021

Identification of

Natalia Hernandez-Pacheco, Mario Gorenjak, Jiang Li, Katja Repnik, Susanne J Vijverberg, Vojko Berce, Andrea Jorgensen, Leila Karimi, Maximilian Schieck, Lesly-Anne Samedy-Bates and 15 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Asthma and Chronic Obstructive Pulmonary Disease.Clinics in chest medicine · 2023
    Review
  3. Asthma Exacerbations: The Genes Behind the Scenes.Journal of investigational allergology & clinical immunology · 2023
    Review
  4. Precision Medicine in Asthma Therapy.Handbook of experimental pharmacology · 2023
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 12 institutions in 7 countries.

Natalia Hernandez-PachecoResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Carretera General del Rosario 145, 38010 Santa Cruz de Tenerife, Spain.
Mario GorenjakCenter for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Taborska Ulica 8, 2000 Maribor, Slovenia.ORCID 0000-0003-4208-9683
Jiang LiThe Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.ORCID 0000-0002-9791-2553
Katja RepnikCenter for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Taborska Ulica 8, 2000 Maribor, Slovenia.
Susanne J VijverbergDepartment of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Vojko BerceCenter for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Taborska Ulica 8, 2000 Maribor, Slovenia.ORCID 0000-0002-0577-8925
Andrea JorgensenDepartment of Biostatistics, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
Leila KarimiDepartment of Medical Informatics, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-1746-3314
Maximilian SchieckDepartment of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Lesly-Anne Samedy-BatesDepartment of Medicine, University of California, San Francisco, CA 94143, USA.
Roger TavendalePopulation Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital, and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Jesús VillarCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Avenida de Monforte de Lemos, 5, 28029 Madrid, Spain.ORCID 0000-0001-5687-3562
Somnath MukhopadhyayPopulation Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital, and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Munir PirmohamedDepartment of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, 200 London Rd, Liverpool L3 9TA, UK.ORCID 0000-0002-7534-7266
Katia M C VerhammeDepartment of Medical Informatics, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Michael KabeschDepartment of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Daniel B HawcuttDepartment of Women's and Children's Health, University of Liverpool, Liverpool L69 3BX, UK.
Steve TurnerChild Health, University of Aberdeen, King's College, Aberdeen AB24 3FX, UK.ORCID 0000-0001-8393-5060
Colin N PalmerPopulation Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital, and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Kelan G TantisiraThe Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.
Esteban G BurchardDepartment of Medicine, University of California, San Francisco, CA 94143, USA.
Anke H Maitland-van der ZeeDepartment of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-0414-3442
Carlos FloresResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Carretera General del Rosario 145, 38010 Santa Cruz de Tenerife, Spain.ORCID 0000-0001-5352-069X
Uroš PotočnikCenter for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Taborska Ulica 8, 2000 Maribor, Slovenia.ORCID 0000-0003-1624-9428
Maria Pino-YanesGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez s/n, Faculty of Science, Apartado 456, 38200 San Cristóbal de La Laguna, Spain.ORCID 0000-0003-0332-437X
University of Maribor · SIUniversidad de La Laguna · ESUniversity of Liverpool · GBBrigham and Women's Hospital · USErasmus MC · NLUniversity Hospital Regensburg · DEUniversity of California, San Francisco · USUniversity of Dundee · GBUtrecht University · NLBrighton and Sussex Medical School · GBSt. Michael's Hospital · CAUniversity of Aberdeen · GB

Funding

The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
CLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
LEARNED MODIFICATION OF VISCERAL FUNCTION IN MANZ01AG000067 · NIA · AGING · PI ENGEL, B T · 1985 to 1988
–
ERACoSysMed 1st Joint Transnational Call from the European Union under the Horizon 2020 SysPharmPediaGlaxoSmithKline NAInstituto de Salud Carlos III (ISCIII) through Strategic Action for Health Research (AES) and European Community (EC) within the Active and Assisted Living (AAL) Programme framework AC15/00015ISCIII and European Regional Development Fund PT17/0019ISCIII, European Regional Development Fund FI16/00136Ministry of Education, Science and Sport Slovenia C3330-16-500106National Heart, Lung, and Blood Institute of the National Institute of Health R01HL117004National Heart, Lung, and Blood Institute of the National Institute of Health X01HL134589National Institute of General Medical Sciences of the National Institutes of Health 5T32GM007546-42NHS Chair of Pharmacogenetics via the UK Department of Health NANHS Research Scotland and The Wellcome Trust Biomedical Resource 099177/Z/12/ZNIEHS NIH HHS R01ES015794Sandler Family Foundation, the American Asthma Foundation, the RWJF Amos Medical Faculty Development Program, Harry Wm. and Diana V. Hind Distinguished Professor in Pharmaceutical Sciences II NASlovenian Research Agency P3-0067Spanish Ministry of Economy, Industry and Competitiveness RYC-2015-17205Spanish Ministry of Science, Innovation, and Universities, the State Research Agency, and the European Regional Development Fund from the European Union SAF2017-83417RUtrecht Institute for Pharmaceutical Sciences NAZonMw 113201006
6 · The paper itself

Abstract

Inhaled corticosteroids (ICS) are the most common asthma controller medication. An important contribution of genetic factors in ICS response has been evidenced. Here, we aimed to identify novel genetic markers involved in ICS response in asthma. A genome-wide association study (GWAS) of the change in lung function after 6 weeks of ICS treatment was performed in 166 asthma patients from the SLOVENIA study. Patients with an improvement in lung function ≥8% were considered as ICS responders. Suggestively associated variants (

Indexed as

childhood asthmaexacerbationsforced expiratory volume in one secondgenome-wide association studyinhaled corticosteroidssingle nucleotide polymorphism

Identifiers

PMID34442380
PMCPMC8399629
OpenAlexW3186162585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.