Evidence map›Paper›PMID 34442367›Full record

ArticleJournal of personalized medicine2021

Feasibly of CD24/CD11b as a Screening Test for Hematological Malignancies.

Shiran Shapira, Dina Kazanov, Fatin Mdah, Hadas Yaakobi, Yair Herishanu, Chava Perry, Irit Avivi, Gilad Itchaki, Adi Shacham-Abulafia, Pia Raanani and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. A Phase 1 First-in-Human Study of the MCL-1 Inhibitor AZD5991 in Patients with Relapsed/Refractory Hematologic Malignancies.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  6. Review
  7. Targeting CD24 as a novel immunotherapy for solid cancers.Cell communication and signaling : CCS · 2023
    Review
  8. CD24: A Novel Target for Cancer Immunotherapy.Journal of personalized medicine · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Shiran ShapiraIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Dina KazanovIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Fatin MdahIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Hadas YaakobiIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Yair HerishanuSackler Faculty of Medicine, Tel Aviv University, Tel-Aviv 6423906, Israel.
Chava PerrySackler Faculty of Medicine, Tel Aviv University, Tel-Aviv 6423906, Israel.
Irit AviviSackler Faculty of Medicine, Tel Aviv University, Tel-Aviv 6423906, Israel.
Gilad ItchakiSackler Faculty of Medicine, Tel Aviv University, Tel-Aviv 6423906, Israel.
Adi Shacham-AbulafiaSackler Faculty of Medicine, Tel Aviv University, Tel-Aviv 6423906, Israel.
Pia RaananiSackler Faculty of Medicine, Tel Aviv University, Tel-Aviv 6423906, Israel.
Mori Hay-LevyIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Gal AigerIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Jacob MashiahTel Aviv Medical Center, The Pediatric Dermatology Unit, Tel Aviv 6423906, Israel.
Shahar Lev-AriIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.ORCID 0000-0003-0187-9427
Nadir ArberIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Tel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An estimated 1.24 million blood cancer cases occur annually worldwide, accounting for approximately 6% of all cancer cases. Currently, there are no standardized hematology cancer screening tests that are recommended for the general population. CD24 is a mucin-like cell surface molecule and P-selectin ligand, which plays a significant role in the maturation of B-lymphocytes and was found to be overexpressed in a number of hematological malignancies. Our primary aim was to assess the sensitivity and specificity of the CD24/CD11b-based blood test for the detection of hematological malignancies. Our cohort included 488 subjects with positive hematological cancer diagnosis (

Indexed as

biomarkerCD24hematologic cancerpreventionscreening testsensitivityspecificity

Identifiers

PMID34442367
PMCPMC8399145
OpenAlexW3184343763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.