Evidence map›Paper›PMID 34442340›Full record

ReviewJournal of personalized medicine2021

Treatment-Free Remission-A New Aim in the Treatment of Chronic Myeloid Leukemia.

Paulina Kwaśnik, Krzysztof Giannopoulos

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. High Level of CD8Cells · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Paulina KwaśnikDepartment of Experimental Hematooncology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-4244-1213
Krzysztof GiannopoulosDepartment of Experimental Hematooncology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0003-0135-4030
Medical University of Lublin · PL

Funding

Narodowe Centrum Nauki NCN 2018/31/B/NZ6/03361
6 · The paper itself

Abstract

Tyrosine kinases inhibitors (TKIs) revolutionized chronic myeloid leukemia (CML) treatment for many years, prolonging patients' life expectancy to be comparable to age-matched healthy individuals. According to the latest the European LeukemiaNet (ELN) recommendations, CML treatment aims to achieve long-term remission without treatment (TFR), which is feasible in more than 40% of patients. Nearly all molecular relapses occur during the first 6 months after TKI withdrawal and do not progress to clinical relapse. The mechanisms that are responsible for CML relapses remain unexplained. It is suggested that maintaining TFR is not directly related to the total disposing of the gene transcript

Indexed as

chronic myeloid leukemia (CML)TKI withdrawal syndrometreatment-free remission (TFR)tyrosine kinases inhibitors (TKIs)

Identifiers

PMID34442340
PMCPMC8399881
OpenAlexW3183857557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.